{"id":15651,"date":"2018-03-09T09:02:54","date_gmt":"2018-03-09T09:02:54","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/aspectos-immunopatogenicos-de-las-miopatias-inflamatorias\/"},"modified":"2018-03-09T09:02:54","modified_gmt":"2018-03-09T09:02:54","slug":"aspectos-immunopatogenicos-de-las-miopatias-inflamatorias","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/aspectos-immunopatogenicos-de-las-miopatias-inflamatorias\/","title":{"rendered":"Aspectos immunopatog\u00e9nicos de las miopatias inflamatorias"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo Gallardo Vigo <\/strong><\/h2>\n<p>Las miopat\u00edas inflamatorias (mi) se definen como enfermedades musculares con presencia de infiltrados inflamatorios en la biopsia muscular. Hemos estudiado la miositis por cuerpos de inclusi\u00f3n (mci), la dermatomiositis (dm) y las disferlinopat\u00edas (disf) porque hemos conseguido series de enfermos amplias cl\u00ednicamente bien definidas. En el primer trabajo se estudi\u00f3 la frecuencia y posible relevancia inmunopatog\u00e9nica de banda monoclonal (bm) con enfermos con mci. Para ello estudiamos el suero de 70 enfermos con mci y 80 controles. Se analizaron mediante inmunofijaci\u00f3n, inmunohistoqu\u00edmica (ih), anas, inmunoprecipitaci\u00f3n (ip) de arns y western-blot (wb). Un 22.8% de enfermos con mci presentaron banda monoclonal. Los anas y la ip de arns no fueron significativos. Algunos sueros reconoc\u00edan mion\u00facleos por ih. el wb revel\u00f3 reactividad contra diversos ant\u00edgenos musculares con m\u00e1s frecuencia en la mci y bm. Concluimos que la mci, sin tener en cuenta la edad, se asocia con m\u00e1s frecuencia a bm, que a menudo reconoce ant\u00edgenos musculares, especialmente mion\u00facleos, sugiriendo una desregulaci\u00f3n inmunol\u00f3gica. En el segundo i tercer trabajos se estudi\u00f3 el papel de los factores de transcripci\u00f3n stat, y especialmente stat1 en la patogenia de la d. Se estudiaron biopsias de dm, polimiositis (pm), m\u00fasculos isqu\u00e9micos y controles, as\u00ed como cultivos primarios de m\u00fasculo esquel\u00e9tico (cpme) humano estimulados con distintas citoquinas\/factores de crecimiento. El an\u00e1lisis se realiz\u00f3 mediante ih, wb y rt-pcr semicuantitativa. Se observ\u00f3 un aumento de expresi\u00f3n de stat1 en las fibras perifasciculares (fp) en la dm y no en el resto de biopsias estudiadas donde s\u00f3lo hab\u00eda expresi\u00f3n en los infiltrados inflamatorios. en los cpme s\u00f3lo ifn-gamma y no otras citoquinas\/factores de crecimiento estudiados aumentaba la expresi\u00f3n de stat1. Adem\u00e1s se observ\u00f3 una expresi\u00f3n aumentada de catepsinas b y l en las fp y no en las otras miopat\u00edas estudi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Aspectos immunopatog\u00e9nicos de las miopatias inflamatorias<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Aspectos immunopatog\u00e9nicos de las miopatias inflamatorias <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo Gallardo Vigo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isabel Illa Sendra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Grau  veciana <\/li>\n<li>francesc Graus  ribas (vocal)<\/li>\n<li>Jos\u00e9 Berciano blanco (vocal)<\/li>\n<li>josep Mar\u00eda Grau junyent (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo Gallardo Vigo Las miopat\u00edas inflamatorias (mi) se definen como enfermedades musculares con presencia de infiltrados inflamatorios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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