{"id":156553,"date":"2026-01-12T17:30:36","date_gmt":"2026-01-12T17:30:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inhibicion-de-las-colinesterasas-humanas-por-metoclopramida-y-bromopride-consecuencias-y-propuesta-de-un-nuevo-mecanismo-de-accion\/"},"modified":"2026-01-12T17:30:36","modified_gmt":"2026-01-12T17:30:36","slug":"inhibicion-de-las-colinesterasas-humanas-por-metoclopramida-y-bromopride-consecuencias-y-propuesta-de-un-nuevo-mecanismo-de-accion","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/inhibicion-de-las-colinesterasas-humanas-por-metoclopramida-y-bromopride-consecuencias-y-propuesta-de-un-nuevo-mecanismo-de-accion\/","title":{"rendered":"\u00abinhibicion de las colinesterasas humanas por metoclopramida y bromopride: consecuencias y propuesta de un nuevo mecanismo de accion\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Martin Ruiz <\/strong><\/h2>\n<p>Se acepta la existencia de dos tipos de colinesterasas en el hombre. La colinesterasa serica y la acetilcolinesterasa, ambas pertenecen al grupo de las esterasas. En nuestro trabajo se demuestra que las dos enzimas son inhibidas por los farmacos incluidos en el grupo de las ortopramidas, metoclopramida y bromopride.  dicha inhibicion es de caracter reversible y competitivo, haciendose un estudio comparativo con el anestesico local dibucaina.  dado que la accion estimulante de la motilidad gastrointestinal que presentan la metoclopramida y el bromopride se explica, en parte, mediante un determinado efecto colinergico, similar a un aumento en la liberacion de acetilcolina, proponemos que el mecanismo de accion a este nivel es de tipo colinergico indirecto, por inhibicion de las colinesterasas a nivel de las fibras colinergicas que inervan la musculatura lisa enterica.  se observa tambien que ambos farmacos pueden ser utilizados como inhibidores diferenciales de las variantes atipicas de la colinesterasa serica.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>\u00abinhibicion de las colinesterasas humanas por metoclopramida y bromopride: consecuencias y propuesta de un nuevo mecanismo de accion\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 \u00abinhibicion de las colinesterasas humanas por metoclopramida y bromopride: consecuencias y propuesta de un nuevo mecanismo de accion\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Martin Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Sevilla<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Herrera Carranza<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jacobo Cardenas Torres <\/li>\n<li>Elisa Marhuenda Requena (vocal)<\/li>\n<li>Jos\u00e9 Bolufer Gonz\u00e1lez (vocal)<\/li>\n<li>Camilo Fernandez Espina (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Martin Ruiz Se acepta la existencia de dos tipos de colinesterasas en el hombre. La colinesterasa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[160,9,189,561,483,17,10715],"tags":[11296,11334,2342,2946,1267,270632],"class_list":["post-156553","post","type-post","status-publish","format-standard","hentry","category-bioquimica","category-ciencias-medicas","category-farmacodinamia","category-farmacologia-molecular","category-mecanismos-de-accion-de-los-farmacos","category-quimica","category-sevilla","tag-camilo-fernandez-espina","tag-elisa-marhuenda-requena","tag-jacobo-cardenas-torres","tag-joaquin-herrera-carranza","tag-jose-bolufer-gonzalez","tag-manuel-martin-ruiz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/156553","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=156553"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/156553\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=156553"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=156553"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=156553"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}