{"id":156692,"date":"2026-01-12T17:31:44","date_gmt":"2026-01-12T17:31:44","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-genica-de-virus-herpes-simplex-tipo-i-en-un-modelo-de-latencia-in-vitro\/"},"modified":"2026-01-12T17:31:44","modified_gmt":"2026-01-12T17:31:44","slug":"analisis-de-la-expresion-genica-de-virus-herpes-simplex-tipo-i-en-un-modelo-de-latencia-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/analisis-de-la-expresion-genica-de-virus-herpes-simplex-tipo-i-en-un-modelo-de-latencia-in-vitro\/","title":{"rendered":"Analisis de la expresion genica de virus herpes simplex tipo i en un modelo de latencia \u00abin vitro\u00bb."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Vicente Catalan Cuenca <\/strong><\/h2>\n<p>Virus herpes simplex tipo 1 (uhs-1) puede permanecer en estado latente en neuronas de individuos que han tenido una infeccion productiva. Empleando modelos animales se ha comprobado que durante la latencia, la expresion genica de uhs-1 se encuentra reducida a dos transcritos de rna (lats) de 2 y 15 kb que son expresados a bajo nivel durante la reactivacion, detectandose durante la infeccion aguda la expresion a bajo nivel del lat de 2 kb. Debido a la complejidad de los modelos animales es dificil estudiar los mecanismos moleculares de la latencia. Para solventar este problema, hemos desarrollado un sistema de latencia en cultivo celular en el que no se emplean inhibidores quimicos de la replicacion, consiguiendose la latencia infectando a baja m.O.I. E incubando a 42 c, reactivandose el virus tras sobreinfectar con citomegalovirus (hcmv). A diferencia de lo que ocurre \u00abin vivo\u00bb, existe expresion proteica, estando reducida a las proteinas inmediatas tempranas (ie) icpo, icp4, e icp27. Ademas la cinetica de expresion de los lats es similar a la de una infeccion aguda.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analisis de la expresion genica de virus herpes simplex tipo i en un modelo de latencia \u00abin vitro\u00bb.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analisis de la expresion genica de virus herpes simplex tipo i en un modelo de latencia \u00abin vitro\u00bb. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Vicente Catalan Cuenca <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1991<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Garcia De Lomas Barrionuevo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Rodriguez Torres <\/li>\n<li>Evelio Perea Perez (vocal)<\/li>\n<li>Miguel Gobernado Serrano (vocal)<\/li>\n<li>Ramon Cisterna Cancer (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Vicente Catalan Cuenca Virus herpes simplex tipo 1 (uhs-1) puede permanecer en estado latente en neuronas de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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