{"id":15675,"date":"2018-03-09T09:02:56","date_gmt":"2018-03-09T09:02:56","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-de-la-expresion-y-significado-de-la-protea%c2%adna-p53-en-lesiones-benignas-displasicas-y-malignas-de-laringe\/"},"modified":"2018-03-09T09:02:56","modified_gmt":"2018-03-09T09:02:56","slug":"valoracion-de-la-expresion-y-significado-de-la-protea%c2%adna-p53-en-lesiones-benignas-displasicas-y-malignas-de-laringe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-de-la-expresion-y-significado-de-la-protea%c2%adna-p53-en-lesiones-benignas-displasicas-y-malignas-de-laringe\/","title":{"rendered":"Valoraci\u00f3n de la expresi\u00f3n y significado de la prote\u00edna p53 en lesiones benignas, displ\u00e1sicas y malignas de laringe"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Avalos Serrano Encarnaci\u00f3n M. <\/strong><\/h2>\n<p>El proceso de la carcinog\u00e9nesis a nivel de la laringe se desarrolla a trav\u00e9s de m\u00faltiples etapas algunas de las cuales son reconocidas histol\u00f3gicamente correspondiendo a los grados de displasia. El papel del gen p53 en el desarrollo del c\u00e1ncer humano ha sido demostrado en un amplio rango de tumores. A nivel laringeo las alteraciones del p53 son un fen\u00f3meno precoz en la transformaci\u00f3n maligna, observ\u00e1ndose su expresi\u00f3n inmunohistoqu\u00edmica en lesiones displ\u00e1sicas laringeas. Su valor como potencial biomarcador en la progresi\u00f3n a la malignidad de las lesiones displ\u00e1sicas y como factor pron\u00f3stico en el c\u00e1ncer de laringe permanece controvertido.  material y m\u00e9todos  se han estudiado 135 pacientes diagnosticados en el hospital puerta del mar de c\u00e1diz. Del total 21 casos corresponden a lesiones benignas y 34 displasias no relacionadas con c\u00e1ncer. Los 80 casos restantes corresponden a carcinomas epidermoides de laringe, en los que se han valorado una serie de factores cl\u00ednicopatol\u00f3gicos a nivel tumoral y ganglionar, donde se han estudiado 78 displasias peritumorales y 79 epitelio normales. Todas las muestras son fijadas en formol e incluidas en parafina. Estudiamos la expresi\u00f3n inmunohistoqu\u00edmica de p53 usando el m\u00e9todo de la peroxidasa a 37\u00c2\u00bac con el sistema automatizado \u00abventana es\u00bb y el anticuerpo monoclonal do7, empleando desenmascaramiento antig\u00e9nico mediante calentamiento en olla a presi\u00f3n. en las lesiones benignas, displasia y epitelio normal se valora la expresi\u00f3n nuclear de p53 y en el caso de positividad su localizaci\u00f3n y extensi\u00f3n. en los carcinomas se valora como positiva la tinci\u00f3n mayor al 10% de c\u00e9lulas tumorales. Relacionamos la expresi\u00f3n de p53 con los factores clinicopatol\u00f3gicos estudiados  y con la supervivencia conocida a 5 a\u00f1os realizando un an\u00e1lisis univariante y multivariante.  conclusiones  1,- en los carcinomas de laringe la presencia de expresi\u00f3n p53 en epitelios normales peritumorale<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoraci\u00f3n de la expresi\u00f3n y significado de la prote\u00edna p53 en lesiones benignas, displ\u00e1sicas y malignas de laringe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n de la expresi\u00f3n y significado de la prote\u00edna p53 en lesiones benignas, displ\u00e1sicas y malignas de laringe <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Avalos Serrano Encarnaci\u00f3n M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00e1diz<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Mart\u00ednez L\u00f3pez M. Carmen<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Lopez  mu\u00f1oz <\/li>\n<li>Ana Fern\u00e1ndez rodr\u00edguez (vocal)<\/li>\n<li>in\u00e9s Mart\u00edn lacave (vocal)<\/li>\n<li>Manuel Sainz quevedo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Avalos Serrano Encarnaci\u00f3n M. El proceso de la carcinog\u00e9nesis a nivel de la laringe se desarrolla a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[1506,155,9,52,1226,156],"tags":[11201,1713,49884,11198,35779,20627],"class_list":["post-15675","post","type-post","status-publish","format-standard","hentry","category-cadiz","category-ciencias-clinicas","category-ciencias-medicas","category-histopatologia","category-otorrinolaringologia","category-patologia","tag-ana-fernandez-rodriguez","tag-antonio-lopez-munoz","tag-avalos-serrano-encarnacion-m","tag-ines-martin-lacave","tag-manuel-sainz-quevedo","tag-Martinez-lopez-m-carmen"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15675","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15675"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15675\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15675"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15675"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15675"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}