{"id":15757,"date":"2018-03-09T09:03:03","date_gmt":"2018-03-09T09:03:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/alteraciones-hematologicas-y-de-la-coagulacion-en-el-xenotrasplante-ortotopico-hepatico-de-cerdo-a-babuino\/"},"modified":"2018-03-09T09:03:03","modified_gmt":"2018-03-09T09:03:03","slug":"alteraciones-hematologicas-y-de-la-coagulacion-en-el-xenotrasplante-ortotopico-hepatico-de-cerdo-a-babuino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/alteraciones-hematologicas-y-de-la-coagulacion-en-el-xenotrasplante-ortotopico-hepatico-de-cerdo-a-babuino\/","title":{"rendered":"Alteraciones hematol\u00f3gicas y de la coagulaci\u00f3n en el xenotrasplante ortotopico hep\u00e1tico de cerdo a babuino"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Majado Mart\u00ednez M. Juliana <\/strong><\/h2>\n<p>Introducci\u00f3n  la falta de \u00f3rganos humanos para trasplantes alog\u00e9nicos ha propiciado la b\u00fasqueda de otras alternativas para paliar esta deficiencia, entre ellas se encuentra la posible utilizaci\u00f3n de donantes de otras especies. El xenotrasplante como una de las posibles soluciones al problema de la escasez de \u00f3rganos humanos ha cobrado inter\u00e9s en los \u00faltimos a\u00f1os, especialmente por el avance de las ciencias biom\u00e9dicas. El problema principal con el que hay que enfrentarse en el xenotrasplante es el del rechazo hiperagudo (rha) producido por los anticuerpos que existen de manera natural en los individuos de una especie frente a los de otra especie discordante. El rha se ha intentado paliar mediante varios procedimientos, como la deplecci\u00f3n de xenoanticuerpos del plasma del receptor, la inactivaci\u00f3n del complemento o la utilizaci\u00f3n de \u00f3rganos procedentes de animales transg\u00e9nicos para genes reguladores de la activaci\u00f3n del complemento.  objetivos  1,- objetivos previos a la realizaci\u00f3n del xenotraspalnte:  a,- an\u00e1lisis del efecto de la perfusi\u00f3n de plasma humano a trav\u00e9s de \u00f3rganos porcinos sobre los xenoanticuerpos (xac) y la coagulaci\u00f3n.  b,- estudio de la compatibilidad humoral entre donantes y receptor del xenotrasplante, para usarlo como criterio de selecci\u00f3n mediante el an\u00e1lisis de los niveles de xac en los posibles receptores frente a cada uno de los donantes potenciales.  c,- elaboraci\u00f3n de la log\u00edstica adecuada para preparar un banco de hemoderivados \u00f3ptimo que asegure una hemoterapia eficaz en los xtoh, mediante el estuido de la compatibilidad sangu\u00ednea de todos los babuinos de la colonia.  2,- objetivos espec\u00edficos del estudio hematol\u00f3gico durante las fases del trasplante:  a,- estudio comparativo de la evoluci\u00f3n de los par\u00e1metros hematol\u00f3gicos, de los factores de la coagulaci\u00f3n y de los xac entre los xtoh controles y h-daf, durante las diferentes fases del xtoh.  b,- estudio de la evoluc<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Alteraciones hematol\u00f3gicas y de la coagulaci\u00f3n en el xenotrasplante ortotopico hep\u00e1tico de cerdo a babuino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Alteraciones hematol\u00f3gicas y de la coagulaci\u00f3n en el xenotrasplante ortotopico hep\u00e1tico de cerdo a babuino <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Majado Mart\u00ednez M. Juliana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Murcia<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pablo Ram\u00edrez Romero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduard Jaurrieta mas <\/li>\n<li>Antonio Mu\u00f1oz luna (vocal)<\/li>\n<li>Rafael Chavez cartaya (vocal)<\/li>\n<li> Lamana luzurriaga M\u00aa Luisa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Majado Mart\u00ednez M. Juliana Introducci\u00f3n la falta de \u00f3rganos humanos para trasplantes alog\u00e9nicos ha propiciado la b\u00fasqueda [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,10,1279,8235],"tags":[8715,1460,50105,50102,50103,50104],"class_list":["post-15757","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-de-trasplantes","category-cirugia-experimental","category-murcia","tag-antonio-munoz-luna","tag-eduard-jaurrieta-mas","tag-lamana-luzurriaga-ma-luisa","tag-majado-Martinez-m-juliana","tag-pablo-ramirez-romero","tag-rafael-chavez-cartaya"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15757"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15757\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15757"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15757"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}