{"id":15794,"date":"2018-03-09T09:03:06","date_gmt":"2018-03-09T09:03:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-biologa%c2%ada-del-factor-de-celulas-stem-y-su-receptor-c-kit\/"},"modified":"2018-03-09T09:03:06","modified_gmt":"2018-03-09T09:03:06","slug":"bases-moleculares-de-la-biologa%c2%ada-del-factor-de-celulas-stem-y-su-receptor-c-kit","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/bases-moleculares-de-la-biologa%c2%ada-del-factor-de-celulas-stem-y-su-receptor-c-kit\/","title":{"rendered":"Bases moleculares de la biolog\u00eda del factor de c\u00e9lulas stem y su receptor c-kit"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  S\u00e1nchez Mart\u00edn Manuel Adolfo <\/strong><\/h2>\n<p>La hematopoyesis es un proceso din\u00e1mico, regulado y que responde a las distintas necesidades biol\u00f3gicas del organismo. La producci\u00f3n de c\u00e9lulas hematopoy\u00e9ticas est\u00e1 coordinada por los efectos de un gran n\u00famero de citocinas, hormonas y factores de crecimiento. Una de estas citocinas es el factor de c\u00e9lulas stem (scf), el cual media su acci\u00f3n uni\u00e9ndose al receptor c-kit. ambos juegan un papel indispensable no s\u00f3lo en la hematopoyesis sino tambi\u00e9n en la generaci\u00f3n de melanocitos, c\u00e9lulas germinales y otros procesos. Durante la embriog\u00e9nesis scf\/c-kit participa en la migraci\u00f3n de c\u00e9lulas hematopoy\u00e9ticas desde la regi\u00f3n aorta-g\u00f3nada-mesonefro (agm) hasta el h\u00edgado fetal y m\u00e9dula \u00f3sea. Scf\/c-kit participa en la diferenciaci\u00f3n y movilizaci\u00f3n de progenitores mieloides y eritroides desde la m\u00e9dula \u00f3sea hacia la sangre per\u00edferica y \u00f3rganos linfoides secundarios. Estos procesos de migraci\u00f3n y diferenciaci\u00f3n celular implican una p\u00e9rdida de los anclajes de las c\u00e9lulas progenitoras con el estroma, una adquisici\u00f3n de la capacidad migratoria as\u00ed como una resistencia a la apoptosis.  desde que en 1990 el scf fuera identificado como el ligando de c-kit, han sido numerosos los trabajos publicados acerca de las v\u00edas que activa y las implicaciones de \u00e9stas en las diferentes respuestas biol\u00f3gicas. Sin embargo, no se conocen los mecanismos moleculares espec\u00edficos que median la funci\u00f3n de c-kit. No obstante en los \u00faltimos a\u00f1os se han identificados familias de factores de transcripci\u00f3n que espec\u00edficamente median procesos biol\u00f3gicos semejantes a los mediados por c-kit, como son la familia de prote\u00ednas snail. Dado que las funciones biol\u00f3gicas en las que intervienen tanto scf\/c-kit como la familia snail son similares, el objeto de este estudio fue comprobar si la familia de factores de transcripci\u00f3n snail media las funciones biol\u00f3gicas que lleva a cabo c-kit en hematopoyesis, melanog\u00e9nesis y gametog\u00e9nesis.  los res<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la biolog\u00eda del factor de c\u00e9lulas stem y su receptor c-kit<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la biolog\u00eda del factor de c\u00e9lulas stem y su receptor c-kit <\/li>\n<li><strong>Autor:<\/strong>\u00a0  S\u00e1nchez Mart\u00edn Manuel Adolfo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Isdiro S\u00e1nchez Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas fernando San Miguel izquierdo <\/li>\n<li>\u00e1ngela Nieto M\u00aa (vocal)<\/li>\n<li>bel\u00e9n Pintado sanJuan benito (vocal)<\/li>\n<li>Antonio Bernard (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de S\u00e1nchez Mart\u00edn Manuel Adolfo La hematopoyesis es un proceso din\u00e1mico, regulado y que responde a las distintas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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