{"id":15796,"date":"2018-03-09T09:03:06","date_gmt":"2018-03-09T09:03:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-los-neutrofilos-en-la-regulacion-de-las-plaquetas-y-su-modulacion-por-el-oxido-nitrico-efecto-de-la-presencia-de-aspirina-y-carvedilol\/"},"modified":"2018-03-09T09:03:06","modified_gmt":"2018-03-09T09:03:06","slug":"papel-de-los-neutrofilos-en-la-regulacion-de-las-plaquetas-y-su-modulacion-por-el-oxido-nitrico-efecto-de-la-presencia-de-aspirina-y-carvedilol","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-los-neutrofilos-en-la-regulacion-de-las-plaquetas-y-su-modulacion-por-el-oxido-nitrico-efecto-de-la-presencia-de-aspirina-y-carvedilol\/","title":{"rendered":"Papel de los neutrofilos en la regulaci\u00f3n de las plaquetas y su modulaci\u00f3n por el oxido nitrico: efecto de la presencia de aspirina y carvedilol"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Belluer \u00e1lvarez Teresa M. <\/strong><\/h2>\n<p>Esta tesis describe hallazgos novedosos acerca de la implicaci\u00f3n del neutr\u00f3filo en la agregaci\u00f3n plaquetaria y el papel que en esta relaci\u00f3n juegan f\u00e1rmacos como la aspirina o el cardedilol a trav\u00e9s del \u00f3xido n\u00edtrico. los datos recogidos en esta tesis corroboran los mecanismos de actuaci\u00f3n ya conocidos de la aspirina y describen otras v\u00edas por las que la aspirina inhibe la agregaci\u00f3n plaquetaria a trav\u00e9s de los neutr\u00f3filos, y descubren nuevos caminos de acci\u00f3n en este terreno de otros f\u00e1rmacos de creciente inter\u00e9s, tanto a nivel investigador como en la pr\u00e1ctica cl\u00ednica, como es el caso del carvedilol en su relaci\u00f3n con los neutr\u00f3filos activados, su acci\u00f3n frente a la agregaci\u00f3n plaquetaria y la implicaci\u00f3n del \u00f3xido n\u00edtrico, poniendo de manifiesto la importancia del efecto \u00abscavenger\u00bb del carvedilol sobre los radicales libres de ox\u00edgeno en estos procesos. Con los resultados obtenidos en esta tesis se demuestra que la aspirina inhibe la agregaci\u00f3n plaquetaria a trav\u00e9s de aumentar la producci\u00f3n de no por los neutr\u00f3filos no activados, implicando al sistema no\/gmpc. Por el contrario, los neutr\u00f3filos activados ejercen un efecto proagregante plaquetario al tener estimulada la formaci\u00f3n de ani\u00f3n super\u00f3xido, principal catabolizador del \u00f3xido n\u00edtrico. el carvedilol secuestra a este ani\u00f3n super\u00f3xido inhibiendo, por tanto, el efecto proagregante plaquetario del neutr\u00f3filo estimulado. Los resultados obtenidos abren nuevas v\u00edas de investigaci\u00f3n sobre el efecto conjunto de estos dos f\u00e1rmacos, carvedilol y aspirina, en la agregaci\u00f3n plaquetaria ya que ambos inhiben esta agregaci\u00f3n por mecanismos distintos pero interrelacionados, pues el i\u00f3n super\u00f3xido es el principal catabolilzador del \u00f3xido n\u00edtrico, y se ha comprobado que la administraci\u00f3n conjunta de ambos f\u00e1rmacos tiene mayor efecto antiagregante plaquetario que cada uno por separado.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de los neutrofilos en la regulaci\u00f3n de las plaquetas y su modulaci\u00f3n por el oxido nitrico: efecto de la presencia de aspirina y carvedilol<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de los neutrofilos en la regulaci\u00f3n de las plaquetas y su modulaci\u00f3n por el oxido nitrico: efecto de la presencia de aspirina y carvedilol <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Belluer \u00e1lvarez Teresa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio L\u00f3pez Farr\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Oya otero <\/li>\n<li>Juan Tamarco men\u00e9ndez (vocal)<\/li>\n<li>Jos\u00e9 Marco Martinez (vocal)<\/li>\n<li>ricardo Jos\u00e9 Bosch mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Belluer \u00e1lvarez Teresa M. Esta tesis describe hallazgos novedosos acerca de la implicaci\u00f3n del neutr\u00f3filo en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[932,9,139],"tags":[14976,50214,15484,50215,2097,49638],"class_list":["post-15796","post","type-post","status-publish","format-standard","hentry","category-cardiologia","category-ciencias-medicas","category-medicina-interna","tag-antonio-lopez-farre","tag-belluer-alvarez-teresa-m","tag-jose-marco-Martinez","tag-juan-tamarco-menendez","tag-manuel-oya-otero","tag-ricardo-jose-bosch-Martinez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15796","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15796"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15796\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15796"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15796"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15796"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}