{"id":15807,"date":"2018-03-09T09:03:07","date_gmt":"2018-03-09T09:03:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/utilizacion-de-antioxidantes-no-enzimaticos-en-la-prevencion-de-la-peroxidacion-lipa%c2%addica-y-el-riesgo-aterogenico-en-la-diabetes-mellitus-tipo-1\/"},"modified":"2018-03-09T09:03:07","modified_gmt":"2018-03-09T09:03:07","slug":"utilizacion-de-antioxidantes-no-enzimaticos-en-la-prevencion-de-la-peroxidacion-lipa%c2%addica-y-el-riesgo-aterogenico-en-la-diabetes-mellitus-tipo-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/utilizacion-de-antioxidantes-no-enzimaticos-en-la-prevencion-de-la-peroxidacion-lipa%c2%addica-y-el-riesgo-aterogenico-en-la-diabetes-mellitus-tipo-1\/","title":{"rendered":"Utilizaci\u00f3n de antioxidantes no enzim\u00e1ticos en la prevenci\u00f3n de la peroxidaci\u00f3n lip\u00eddica y el riesgo aterog\u00e9nico en la diabetes mellitus tipo 1"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Enrique Blanca Jover <\/strong><\/h2>\n<p>El estr\u00e9s oxidativo, base de las complicaciones cr\u00f3nicas en la diabetes mellitus se encuentra aumentado debido principalmente al aumento de la peroxidaci\u00f3n lip\u00eddica, y tambi\u00e9n a la disminuci\u00f3n de antioxidantes. En nuestro estudio, realizado sobre una poblaci\u00f3n de 76 ni\u00f1os afectos de diabetes mellitus tipo 1 (edad media de 13,8+-0,28 a\u00f1os y tiempo de evoluci\u00f3n de la enfermedad 5,78+-0,34 a\u00f1os) constatamos ese aumento de la peroxidaci\u00f3n lip\u00eddica (lpo) frente a una poblaci\u00f3n de ni\u00f1os sanos mediante la determinaci\u00f3n conjunta de dos de sus par\u00e1metros terminales, el 4-hidroxinonenal y malonildialdeh\u00eddo. asimismo objetivamos una disminuci\u00f3n del mismo tras la realizaci\u00f3n de tratamiento con dosis modestas de vitamina e (10 mg\/kg\/d\u00eda durante un mes), fundamentalmente mediante la valoraci\u00f3n del \u00edndice lpo (vitamina e\/colesterol), propuesto por algunos autores como marcador m\u00e1s sensible de da\u00f1o oxidativo, que llega a estar incluso al nivel de la poblaci\u00f3n sana. Observamos tambi\u00e9n en nuestro estudio un aumento del estr\u00e9s oxidativo en ni\u00f1os diab\u00e9ticos frente a ni\u00f1as, independientemente del control metab\u00f3lico, y entre sexos entre sanos y diab\u00e9ticos.  tambi\u00e9n se analiza el riesgo aterog\u00e9nico, valorando tanto valores lip\u00eddicos, de lipoproteinas e \u00edndices aterog\u00e9nicos confirm\u00e1ndose un aumento conforme empeora el control metab\u00f3lico de la enfermedad.  los antioxidantes no enzim\u00e1ticos (vitamina e, a y selenio), as\u00ed como la prote\u00edna transportadora de retinol (rbp) tambi\u00e9n son estudiados, constat\u00e1ndose un descenso de la vitamina a, ascenso de la vitamina e plasm\u00e1tica y rbp respecto al grupo control de ni\u00f1os sanos. Los cambios en las concentraciones de las vitaminas podr\u00edan ser debidos en el caso de la vitamina a por consumo y en el de la vitamina e como respuesta al incremento oxidativo. Los cambios en la rbp podr\u00edan ocurrir para mejorar el transporte de la vitamina a, relativamente insuficiente. Esta prote\u00edna s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Utilizaci\u00f3n de antioxidantes no enzim\u00e1ticos en la prevenci\u00f3n de la peroxidaci\u00f3n lip\u00eddica y el riesgo aterog\u00e9nico en la diabetes mellitus tipo 1<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Utilizaci\u00f3n de antioxidantes no enzim\u00e1ticos en la prevenci\u00f3n de la peroxidaci\u00f3n lip\u00eddica y el riesgo aterog\u00e9nico en la diabetes mellitus tipo 1 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Enrique Blanca Jover <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rogelio Beyes Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Molina font <\/li>\n<li>angel Gil hernandez (vocal)<\/li>\n<li>Juan  pedro Lopez  siguero (vocal)<\/li>\n<li>montserrat Riveo urgell (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Enrique Blanca Jover El estr\u00e9s oxidativo, base de las complicaciones cr\u00f3nicas en la diabetes mellitus se encuentra [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,851,139],"tags":[3791,50249,3662,42312,50251,50250],"class_list":["post-15807","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-endocrinologia","category-medicina-interna","tag-angel-gil-hernandez","tag-enrique-blanca-jover","tag-juan-antonio-molina-font","tag-juan-pedro-lopez-siguero","tag-montserrat-riveo-urgell","tag-rogelio-beyes-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15807","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15807"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15807\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15807"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15807"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15807"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}