{"id":15809,"date":"2018-03-09T09:03:07","date_gmt":"2018-03-09T09:03:07","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analogos-de-ardeemina-derivados-del-sistema-de-pirazino-21-b-quinazolina-36-diona\/"},"modified":"2018-03-09T09:03:07","modified_gmt":"2018-03-09T09:03:07","slug":"analogos-de-ardeemina-derivados-del-sistema-de-pirazino-21-b-quinazolina-36-diona","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/analogos-de-ardeemina-derivados-del-sistema-de-pirazino-21-b-quinazolina-36-diona\/","title":{"rendered":"Analogos de ardeemina derivados del sistema de pirazino (2,1-b)-quinazolina-3,6-diona."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Cledera Crespo <\/strong><\/h2>\n<p>Se ha puesto a punto la s\u00edntesis de derivados n-sustituidos del sistema de pirazino (2,1-b) quinazolina-3,6-diona a traves del protocolo de eguchi, estudiandose a continuaci\u00f3n, la reactividad de dichos sistemas con aldeh\u00eddos en medio b\u00e1sco. Se observa la obtenci\u00f3n de (z) -1-arilmetilen derivados como productos mayoritarios, con racemizaci\u00f3n parcial del estereocentro.  la reacci\u00f3n de 1,4-diacetil-3-alquil-2,5-piperazinadionas opticamente activas con aldeh\u00eddos proporciona de froma selectiva los (z)-arilmetilen derivados en forma enentiom\u00e9ricamente pura. Estos derivados se pueden transformar en los correspondientes sistemas de pirazino (2,1-b) quinazlolina-3,6-diona a traves del metodo de eguchi, o bien por transformaci\u00f3n en los correspondientes imino\u00e9teres y ciclocondensaci\u00f3n con \u00e1cido antranilico. Esta \u00faltima reacci\u00f3n se acelera notablemente en condiciones de irradiaci\u00f3n con microondas.  se ha desarrollado una nueva metodolog\u00eda que permite la obtenci\u00f3n de 1-acetilpirazino (2,1-b) quinazolina-3,6-dionas sustituidas en posici\u00f3n 4, incluyendo el producto natural gliantripina. Este metodo se basa en una doble ciclaci\u00f3n de sistemas de o-azidobenzoil (aminoacil)glicinato de etilio, primeroo a un derivado de piperazinadiona y despues al triciclo deseado. Los derivados del 1-acetilpirazino (2,1-b) quinazolina-3,6-diona asi obtenidos reaccionan con aldeh\u00eddos en medio b\u00e1sico, con formaci\u00f3n exlusiva de un doble enlace exoc\u00edclico de configuraci\u00f3n z y con mantenimiento de la integridad del estereocentro.  finalmente, se ha estudiado la hidrogenaci\u00f3n catal\u00edtica de los derivados de 1-arilmetilenpirazino (2,1-b) quinazolina-3,6-diona. La reacci\u00f3n conduce a cis derivados como producto exclusivo cuando el compuesto de partida esta sustituido en posici\u00f3n 2, y a mezclas de productos cis y trans cuando no existe dicha sustituci\u00f3n. Adem\u00e1s, se observan productos de hidrogenaci\u00f3n en el anillo aromatico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Analogos de ardeemina derivados del sistema de pirazino (2,1-b)-quinazolina-3,6-diona.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Analogos de ardeemina derivados del sistema de pirazino (2,1-b)-quinazolina-3,6-diona. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Cledera Crespo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/02\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Carlos Menendez Ramos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: monica Sollhuber kretzer <\/li>\n<li>felipe Alcudia gonzalez (vocal)<\/li>\n<li>marcial Moreno ma\u00f1as (vocal)<\/li>\n<li>isidro Sanchez marcos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Cledera Crespo Se ha puesto a punto la s\u00edntesis de derivados n-sustituidos del sistema de pirazino [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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