{"id":15847,"date":"2002-01-03T00:00:00","date_gmt":"2002-01-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valoracion-del-efecto-protector-del-acido-retinoico-administrado-en-el-pera%c2%adodo-prenatal-sobre-la-carcinogenesis-experimental-en-piel-de-ratones-nmri-adultos\/"},"modified":"2002-01-03T00:00:00","modified_gmt":"2002-01-03T00:00:00","slug":"valoracion-del-efecto-protector-del-acido-retinoico-administrado-en-el-pera%c2%adodo-prenatal-sobre-la-carcinogenesis-experimental-en-piel-de-ratones-nmri-adultos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valoracion-del-efecto-protector-del-acido-retinoico-administrado-en-el-pera%c2%adodo-prenatal-sobre-la-carcinogenesis-experimental-en-piel-de-ratones-nmri-adultos\/","title":{"rendered":"Valoraci\u00f3n del efecto protector del \u00e1cido retinoico administrado en el per\u00edodo prenatal sobre la carcinog\u00e9nesis experimental en piel de ratones nmri adultos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosa Ana Garc\u00eda Fern\u00e1ndez <\/strong><\/h2>\n<p>La tesis doctoral se divide en 2 estudios principales, el primero de ellos eval\u00faa el efecto de la exposici\u00f3n in utero a all-trans \u00e1cido retinoico (atar) durante el per\u00edodo prenatal y perinatal, mientras que el segundo se centra en el efecto que esta exposici\u00f3n in utero ejerce en la piel adulta de ratones nmri sometidos a protocolo de carcinog\u00e9nesis qu\u00edmica de piel.  durante el per\u00edodo prenatal y perinatal, la exposici\u00f3n a atar in utero aumentaba el n\u00famero medio de reabsorciones fetales, pero no produc\u00eda malformaciones ni influ\u00eda en la estructura ni en el momento del desarrollo de la epidermis ni de los fol\u00edculos pilosos, de los cuales se hizo una descripci\u00f3n detallada en cada una de sus fases de desarrollo. No obstante, se observ\u00f3 un aumento de la proliferaci\u00f3n de las c\u00e9lulas epiteliales debido a la acci\u00f3n de este retinoide.  en la segunda parte de la tesis doctoral, estudiamos el ciclo de crecimiento del pelo de los ratones nmri para conocer en qu\u00e9 momento del mismo aplic\u00e1bamos el iniciador y el promotor tumoral. Posteriormente, analizamos el efecto de la exposici\u00f3n in utero a atar, y comprobamos que se produc\u00eda una disminuci\u00f3n en la incidencia, multiplicidad y media de presentaci\u00f3n de los tumores, pero que, al mismo tiempo, alteraba la diferenciaci\u00f3n epid\u00e9rmica y favorec\u00eda la progresi\u00f3n maligna de los mismos.  por lo tanto, la exposici\u00f3n in utero a atar aunque ten\u00eda un cierto efecto quimiopreventivo, estaba desaconsejada pues potenciaba la progresi\u00f3n maligna de los tumores que se desarrollaban, a lo que deb\u00eda a\u00f1adirse el incremento en el n\u00famero de abortos que provocaba este retinoide durante el per\u00edodo fetal.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valoraci\u00f3n del efecto protector del \u00e1cido retinoico administrado en el per\u00edodo prenatal sobre la carcinog\u00e9nesis experimental en piel de ratones nmri adultos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valoraci\u00f3n del efecto protector del \u00e1cido retinoico administrado en el per\u00edodo prenatal sobre la carcinog\u00e9nesis experimental en piel de ratones nmri adultos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosa Ana Garc\u00eda Fern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Le\u00f3n<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Garc\u00eda Iglesias M. Jos\u00e9<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: alfredo Escudero d\u00edez <\/li>\n<li>Ana isabel Nieto ruiz de z\u00e1rate (vocal)<\/li>\n<li>Elena Mozos  mora (vocal)<\/li>\n<li>laura Luisa Pe\u00f1a fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosa Ana Garc\u00eda Fern\u00e1ndez La tesis doctoral se divide en 2 estudios principales, el primero de ellos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8901,155,9,4430,1027,347,156],"tags":[4564,50349,8485,50348,14465,50347],"class_list":["post-15847","post","type-post","status-publish","format-standard","hentry","category-carcinogenesis","category-ciencias-clinicas","category-ciencias-medicas","category-leon","category-oncologia","category-oncologia-clinica","category-patologia","tag-alfredo-escudero-diez","tag-ana-isabel-nieto-ruiz-de-zarate","tag-elena-mozos-mora","tag-garcia-iglesias-m-jose","tag-laura-luisa-pena-fernandez","tag-rosa-ana-garcia-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15847","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15847"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15847\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15847"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15847"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15847"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}