{"id":15867,"date":"2002-01-03T00:00:00","date_gmt":"2002-01-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-las-mutaciones-del-gen-p53-en-los-tumores-de-celulas-transicionales-de-la-vejiga-urinaria-y-su-implicacion-con-el-pronostico\/"},"modified":"2002-01-03T00:00:00","modified_gmt":"2002-01-03T00:00:00","slug":"determinacion-de-las-mutaciones-del-gen-p53-en-los-tumores-de-celulas-transicionales-de-la-vejiga-urinaria-y-su-implicacion-con-el-pronostico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/determinacion-de-las-mutaciones-del-gen-p53-en-los-tumores-de-celulas-transicionales-de-la-vejiga-urinaria-y-su-implicacion-con-el-pronostico\/","title":{"rendered":"Determinaci\u00f3n de las mutaciones del gen p53 en los tumores de c\u00e9lulas transicionales de la vejiga urinaria y su implicaci\u00f3n con el pron\u00f3stico"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lorenzo Romero Juan  Gabriel <\/strong><\/h2>\n<p>Introducci\u00f3n  los carcinomas de c\u00e9lulas transicionales (cct) representan m\u00e1s del 90% de los tumores de vejiga. El gen p53 est\u00e1 implicado en la g\u00e9nesis y desarrollo de los cct. Mutaciones en este gen supresor ofrecen una ventaja selectiva a las c\u00e9lulas tumorales para crecer sin control.  objetivos  determinar si la existencia de mutaciones en el gen p53 se asocia con grado histol\u00f3gico m\u00e1s indiferenciado, estadios m\u00e1s avanzados y mayor tendencia a la recidiva en los cct vesicales. Se analiz\u00f3 el tipo y la localizaci\u00f3n de las mutaciones, estudiando su efecto en la estructura y funci\u00f3n de p53.  material y m\u00e9todo  estudio descriptivo, anal\u00edtico y transversal sobre 115 pacientes, distribuidos en:  grupo i: control.  grupo ii: cct superficial primario (n=33).  grupo iii: cct superficial recidivante (n=27).  grupo iv: tomor vesical infiltrante (n=34).  el dna tisulares se somete a pcr-sscp (exones 5-9 del gen p53) para detectar posibles mutaciones y se secuencian para caracterizarlas. La variable dependiente considerada fue la existencia de mutaciones en p53, realizando un an\u00e1lisis bivariante y un modelo multivariante de regresi\u00f3n log\u00edstica para estudiar la relaci\u00f3n entre las variables independientes analizadas y la dependiente.  resultados  el 96,8% de los tumores era cct. El 23,5% de los tumores infiltrantes proven\u00eda de cct superficiales recidivantes. El 63,8% de los tumores eran superficiales y, el resto, infiltrantes, de los que el 88,4% fueron de alto grado. Se encontraron mutaciones, por pcr-sscp, en el 46,8% de los pacientes con tumor vesical (61,8% tumor infiltrante\/39,4% superficial), con una tendencia creciente de aparici\u00f3n de mutaciones conforme al tama\u00f1o tumoral y el estadio pt. El 93,2% de las mutaciones apareci\u00f3 en tumores de grados ii y iii, frente al 6,8% en grado i. El 42,3% de las mutaciones aconteci\u00f3 en el ex\u00f3n 8, seguido por el 6 (17,3%), el 7 (15,4%), el 5 (13,5%) y el 9 (11,5%). Perman<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinaci\u00f3n de las mutaciones del gen p53 en los tumores de c\u00e9lulas transicionales de la vejiga urinaria y su implicaci\u00f3n con el pron\u00f3stico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinaci\u00f3n de las mutaciones del gen p53 en los tumores de c\u00e9lulas transicionales de la vejiga urinaria y su implicaci\u00f3n con el pron\u00f3stico <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lorenzo Romero Juan  Gabriel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Rodr\u00edguez Montes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: remigio Vela navarrete <\/li>\n<li>julio Antonio Virseda rodriguez (vocal)<\/li>\n<li>Francisco Arnalich fern\u00e1ndez (vocal)<\/li>\n<li>julio Escribano Martinez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorenzo Romero Juan Gabriel Introducci\u00f3n los carcinomas de c\u00e9lulas transicionales (cct) representan m\u00e1s del 90% de los 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