{"id":15889,"date":"2002-04-03T00:00:00","date_gmt":"2002-04-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-accion-antiinflamatoria-del-donador-exogeno-de-oxido-na%c2%adtrico-nitroglicerina-en-la-arteriopata%c2%ada-oclusiva-periferica-de-origen-arteriosclerotico\/"},"modified":"2002-04-03T00:00:00","modified_gmt":"2002-04-03T00:00:00","slug":"estudio-de-la-accion-antiinflamatoria-del-donador-exogeno-de-oxido-na%c2%adtrico-nitroglicerina-en-la-arteriopata%c2%ada-oclusiva-periferica-de-origen-arteriosclerotico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-accion-antiinflamatoria-del-donador-exogeno-de-oxido-na%c2%adtrico-nitroglicerina-en-la-arteriopata%c2%ada-oclusiva-periferica-de-origen-arteriosclerotico\/","title":{"rendered":"Estudio de la acci\u00f3n antiinflamatoria del donador ex\u00f3geno de \u00f3xido n\u00edtrico nitroglicerina en la arteriopat\u00edaoclusiva perif\u00e9rica de origen arterioscler\u00f3tico"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Isabel Sampedro Garc\u00eda <\/strong><\/h2>\n<p>En pacientes con diagn\u00f3stico cl\u00ednico y radiol\u00f3gico de arteriopat\u00eda oclusiva perif\u00e9rica (aop), se hace un estudio prospectivo, doble ciego de nitroglicerina contrastado frente a placebo donde se valora la evoluci\u00f3n cl\u00ednica subjetiva y par\u00e1metros bioqu\u00edmicos inflamatorios y de disfunci\u00f3n endotelial (pcr, fibrin\u00f3geno, vsg, il-6, tnf-alfa, selectina-e, vcam e icam-1 solubles y el factor von willebrand) as\u00ed como par\u00e1metros de la v\u00eda l-arginina: on (nitritos y nitratos, gmpc plasm\u00e1tico e intraplaquetario). Y adem\u00e1s se realiza un estudio de todos estos par\u00e1metros bioqu\u00edmicos basales frente a controles sanos. Los resultados confirman que la aop una enfermedad inflamatoria ya que est\u00e1n elevados los reactantes de fase aguda pcr y fibrin\u00f3geno, la il-6 y las mol\u00e9culas de adhesi\u00f3n vascular vcam e icam, as\u00ed como el vwf. tambi\u00e9n hay en estos pacientes evidencia bioqu\u00edmica de alteraci\u00f3n en la v\u00eda de la l-arginina: on, con descenso en la concentraci\u00f3n del mediador gmpc plasm\u00e1tico. El tratamiento con la nitroglicerina transd\u00e9rmica mejora cl\u00ednicamente la valoraci\u00f3n subjetiva de los pacientes con aop y parece mejorar tambi\u00e9n la capacidad de marcha sin dolor. De manera significativa la nitroglicerina transd\u00e9rmica disminuye la concentraci\u00f3n de par\u00e1metros inflamatorios como la prote\u00edna c reactiva, y la expresi\u00f3n de la mol\u00e9cula de adhesi\u00f3n endotelial selectina-e. Y se observa una tendencia al descenso de il-6 e icam-1 cuando los valores basales est\u00e1n elevados. Cl\u00ednicamente la ntg, aumenta la concentraci\u00f3n de tnf-alfa por un mecanismo a\u00fan no bien conocido. En resumen este trabajo muestra por primera vez en humanos, a nivel bioqu\u00edmico que la ntg transd\u00e9rmica adem\u00e1s de su acci\u00f3n vasodilatadora es capaz de disminuir la activaci\u00f3n inflamatoria de la pared arterial de los pacientes con arteriosclerosis a nivel perif\u00e9rico.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la acci\u00f3n antiinflamatoria del donador ex\u00f3geno de \u00f3xido n\u00edtrico nitroglicerina en la arteriopat\u00edaoclusiva perif\u00e9rica de origen arterioscler\u00f3tico<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la acci\u00f3n antiinflamatoria del donador ex\u00f3geno de \u00f3xido n\u00edtrico nitroglicerina en la arteriopat\u00edaoclusiva perif\u00e9rica de origen arterioscler\u00f3tico <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Isabel Sampedro Garc\u00eda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Cantabria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Berrazueta Fern\u00e1ndez Jos\u00e9 Ram\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Amado se\u00f1aris <\/li>\n<li> De artaza andrade Manuel (vocal)<\/li>\n<li>Andr\u00e9s Gonz\u00e1lez tutor (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Isabel Sampedro Garc\u00eda En pacientes con diagn\u00f3stico cl\u00ednico y radiol\u00f3gico de arteriopat\u00eda oclusiva perif\u00e9rica (aop), se hace [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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