{"id":15903,"date":"2002-05-03T00:00:00","date_gmt":"2002-05-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-epidemiologico-y-molecular-del-cancer-pediatrico-factores-constitucionales-predisponentes-y-analisis-molecular-de-los-genes-p53-y-p161ink4\/"},"modified":"2002-05-03T00:00:00","modified_gmt":"2002-05-03T00:00:00","slug":"estudio-epidemiologico-y-molecular-del-cancer-pediatrico-factores-constitucionales-predisponentes-y-analisis-molecular-de-los-genes-p53-y-p161ink4","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-epidemiologico-y-molecular-del-cancer-pediatrico-factores-constitucionales-predisponentes-y-analisis-molecular-de-los-genes-p53-y-p161ink4\/","title":{"rendered":"Estudio epidemiologico y molecular del cancer pediatrico: factores constitucionales predisponentes y analisis molecular de los genes p53 y p161ink4"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Fernandez-tejeiro Alvarez <\/strong><\/h2>\n<p>Objetivos: analizar la agregaci\u00f3n familiar de c\u00e1ncer en ni\u00f1os diagnosticados de neoplasias malignas. Determinar si la presencia de mutaci\u00f3n germinal de los genes p53 y p16 se asocia con la aparici\u00f3n de neoplasias en ni\u00f1os con antecedente familiar de cancer antes de los 45 a\u00f1os.  dise\u00f1o: estudio casos y controles. Ambito de estudio: unidad de oncolog\u00eda ped\u00edatrica del hospital de cruces con una cobertura del 75% de las neoplasias pedi\u00e1tricas en la comunidad aut\u00f3noma vasca.  sujetos de estudio: casos: pacientes menores de 16 a\u00f1os diagnosticados de neoplasia con antecedente familiar de primer o segundo de c\u00e1ncer diagnosticado antes de los 45 a\u00f1os, controles: pacientes menores de 18 a\u00f1os diagnosticados de c\u00e1ncer, sin antecedente familiar de neoplasia.  instrumentalizaci\u00f3n: revisi\u00f3n de historias cl\u00ednicas y entrevista personal para obtenci\u00f3n de datos relativos a los familiares con c\u00e1ncer precoz. Extracci\u00f3n de muestra de sangre para obtenci\u00f3n de adn de los linfocitos de sagre perif\u00e9rica. para el gen p53: amplificaci\u00f3n de adn mediante la t\u00e9cnica de reacci\u00f3n en cadena de polimerasa (pcr) en sangre, estudio del polimorfismo conformacional de cadena simple (sscp) mediante electroforesis del adn en gel de acrilamida, detecci\u00f3n enzim\u00e1tica de mutaciones (emd), y posterior secuenciaci\u00f3n de las posibles mutaciones encontradas. Para el gen p16: estudio del polimorfismo conformacional de cadena simple (sscp).  determinaciones: descripci\u00f3n de la agregaci\u00f3n familiar de c\u00e1ncer observada. preValencia de mutaci\u00f3n germinal de los genes p53 y p16 en casos y controles. caracter\u00edsticas de las mutaciones detectadas. Relaci\u00f3n entre la presencia de mutaci\u00f3n germinal de los dos genes con la agregaci\u00f3n familiar de c\u00e1ncer.  conclusiones: se objetiva agregaci\u00f3n familiar de los tumores t\u00edpicos del s\u00edndrome de li-fraumeni, de los tumores cerebrales y de la neoplasias linfohematol\u00f3gicas. preValencia de mutaciones germinalesdel ge<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio epidemiologico y molecular del cancer pediatrico: factores constitucionales predisponentes y analisis molecular de los genes p53 y p161ink4<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio epidemiologico y molecular del cancer pediatrico: factores constitucionales predisponentes y analisis molecular de los genes p53 y p161ink4 <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Fernandez-tejeiro Alvarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Pa\u00eds vasco\/euskal herriko unibertsitatea<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Aurora Navajas Gutierrez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Rivera pomar <\/li>\n<li>Juan Rodriguez soriano (vocal)<\/li>\n<li>Manuel Bueno sanchez (vocal)<\/li>\n<li>Luis Madero lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Fernandez-tejeiro Alvarez Objetivos: analizar la agregaci\u00f3n familiar de c\u00e1ncer en ni\u00f1os diagnosticados de neoplasias malignas. Determinar [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,1086,347,12909,161],"tags":[50488,50489,13350,26318,21401,2521],"class_list":["post-15903","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-epidemiologia","category-oncologia-clinica","category-pais-vasco-euskal-herriko-unibertsitatea","category-pediatria","tag-ana-fernandez-tejeiro-alvarez","tag-aurora-navajas-gutierrez","tag-jose-maria-rivera-pomar","tag-juan-rodriguez-soriano","tag-luis-madero-lopez","tag-manuel-bueno-sanchez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15903"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15903\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}