{"id":15904,"date":"2002-05-03T00:00:00","date_gmt":"2002-05-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-apoptosis-y-de-la-expresion-de-protea%c2%adnas-involucradas-en-su-control-y-en-los-mecanismos-de-vigilancia-genomica-en-los-tumores-de-ovario-de-estirpe-epitelial\/"},"modified":"2002-05-03T00:00:00","modified_gmt":"2002-05-03T00:00:00","slug":"estudio-de-la-apoptosis-y-de-la-expresion-de-protea%c2%adnas-involucradas-en-su-control-y-en-los-mecanismos-de-vigilancia-genomica-en-los-tumores-de-ovario-de-estirpe-epitelial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-apoptosis-y-de-la-expresion-de-protea%c2%adnas-involucradas-en-su-control-y-en-los-mecanismos-de-vigilancia-genomica-en-los-tumores-de-ovario-de-estirpe-epitelial\/","title":{"rendered":"Estudio de la apoptosis y de la expresi\u00f3n de prote\u00ednas involucradas en su control y en los mecanismos de vigilancia gen\u00f3mica en los tumores de ovario de estirpe epitelial"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco De La Torre Fern\u00e1ndez De Vega <\/strong><\/h2>\n<p>Introducci\u00f3n  los carcinomas de ovario contin\u00faan siendo tumores de muy mal pron\u00f3stico y esto se debe a que la mayor\u00eda de los casos, son ssintom\u00e1ticos en estadios precoces de la enfermedad, y por tanto, se diagnostican en estadios avanzados. un objetivo b\u00e1sico para la investigaci\u00f3n en el c\u00e1ncer de ovario es el conocimiento profundo de su biolog\u00eda y los factores pron\u00f3sticos. La apoptosis es un tipo de muerte celular geneticamente programada y de gran importancia para el mantenimiento de la homeostasis tisular. La expresi\u00f3n de oncogenes, como el bcl-2, y la inactivaci\u00f3n del gen supresor tumoral p53, reduce la susceptibilidad de las c\u00e9lulas para entrar en un programa de apoptosis, mientras que la expresi\u00f3n del bax aumente esta susceptibilidad. Los factores reguladores del ciclo celular, conocidos como mecanismos de vigilancia gen\u00f3mica, se consideran elementos clave en el control de la divisi\u00f3n celular y como procesos fundamentales en la proliferaci\u00f3n celular y, por ende, el c\u00e1ncer. Los genes sprad9 and sphus1 se fosforilan en respuesta a da\u00f1o de dna.  objetivos  considerando que los tumores epiteliales de ovario son un grupo heterog\u00e9neo de neoplasias con diferentes tipos histol\u00f3gicos y distintos grados de actividad biol\u00f3gica, se ha estudiado los mecanismos de apoptosis y de vigilancia gen\u00f3mica, y que son procesos que intervienen en la carcinog\u00e9nesis y en la evoluci\u00f3n de los tumores, as\u00ed como en su respuesta terape\u00fatica.  material y m\u00e9todos  se estudi\u00f3 la sobreexpresi\u00f3n de las prote\u00ednas p53, bcl-2, hus-1 y rad-9 en 130 tumores epiteliales de ovario. El \u00edndice apopt\u00f3tico (c\u00e9lulas apoptoicas\/c\u00e9lulas tumorales en 10 campos de gran aumento-40x-) se evalu\u00f3 mediante el marcaje in situ del dna fragmentado (terminal deoxynucleotydil- transferasa- mediated deoxyuridine triphosphate-biotin nick end-labelling -tunel-) y en secciones te\u00f1idas con hematoxilina-eosina (h-e). Asimismo, se recogieron otras variables c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la apoptosis y de la expresi\u00f3n de prote\u00ednas involucradas en su control y en los mecanismos de vigilancia gen\u00f3mica en los tumores de ovario de estirpe epitelial<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la apoptosis y de la expresi\u00f3n de prote\u00ednas involucradas en su control y en los mecanismos de vigilancia gen\u00f3mica en los tumores de ovario de estirpe epitelial <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco De La Torre Fern\u00e1ndez De Vega <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jordi Xercavins Montosa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Iglesias guiu <\/li>\n<li> Vidal rosell Mar\u00eda teresa (vocal)<\/li>\n<li>Javier Parache hern\u00e1ndez (vocal)<\/li>\n<li>jaume Reventos puigjaner (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco De La Torre Fern\u00e1ndez De Vega Introducci\u00f3n los carcinomas de ovario contin\u00faan siendo tumores de muy [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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