{"id":15926,"date":"2002-07-03T00:00:00","date_gmt":"2002-07-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-lugar-de-implantacion-en-el-comportamiento-biologico-transduccion-de-senal-y-respuesta-a-farmacos-en-xenografts-de-cancer-de-pancreas-y-colon\/"},"modified":"2002-07-03T00:00:00","modified_gmt":"2002-07-03T00:00:00","slug":"influencia-del-lugar-de-implantacion-en-el-comportamiento-biologico-transduccion-de-senal-y-respuesta-a-farmacos-en-xenografts-de-cancer-de-pancreas-y-colon","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/influencia-del-lugar-de-implantacion-en-el-comportamiento-biologico-transduccion-de-senal-y-respuesta-a-farmacos-en-xenografts-de-cancer-de-pancreas-y-colon\/","title":{"rendered":"Influencia del lugar de implantaci\u00f3n en el comportamiento biol\u00f3gico, transducci\u00f3n de se\u00f1al y respuesta a farmacos en xenografts de c\u00e1ncer de pancreas y colon"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Farre Valle <\/strong><\/h2>\n<p>En esta tesis se estudia como el \u00f3rgano en el que se implanta el tumor en el modelo de rat\u00f3n at\u00edmico influye el comportamiento tumoral para el c\u00e1ncer de p\u00e1ncreas y colon comparando la implantaci\u00f3n ortot\u00f3pica con las implantaciones heterot\u00f3picas (subuitis, h\u00edgado y colon) de tumores p\u00e1ncreaticos se observa que el lugar de implantaci\u00f3n modifica:  * el crecimiento tumoral, regulando los procesos de apoptosis y ciclo celular.  * la capacidad invasiva y metast\u00e1sica y los contactos c\u00e9lula a c\u00e9lula a matriz extracelular, la implantaci\u00f3n en el h\u00edgado y en el col\u00f3n provoc\u00f3 un nuevo patr\u00f3n de met\u00e1stasis, no observado en el paciente del que derivaba el tumor.  * la respuesta a los f\u00e1rmacos aplidina y 5-fu comparando el modelo de implantaci\u00f3n subcutania y ortot\u00f3pica. La acci\u00f3n de los f\u00e1rmacos indujo la actuaci\u00f3n  de diferentes v\u00edas de transducci\u00f3n de se\u00f1ales o no projujo efecto  seg\u00fan la localizaci\u00f3n de implantaci\u00f3n del tumor.  se concluy\u00f3 que el lugar de implantaci\u00f3n en el modelo de rat\u00f3n a&#8211; influye el comportamiento de los tumores de pancreas y colon alterando sus v\u00edas de tranasmisi\u00f3n de se\u00f1ales. La respuesta a los f\u00e1rmacos aplidina y 5-fu depende del modelo usado para analizarla y digiere de la observada in vitro.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del lugar de implantaci\u00f3n en el comportamiento biol\u00f3gico, transducci\u00f3n de se\u00f1al y respuesta a farmacos en xenografts de c\u00e1ncer de pancreas y colon<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del lugar de implantaci\u00f3n en el comportamiento biol\u00f3gico, transducci\u00f3n de se\u00f1al y respuesta a farmacos en xenografts de c\u00e1ncer de pancreas y colon <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Farre Valle <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 07\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ram\u00f3n Mangues Bafalluy<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: oriol Bachs valldeneu <\/li>\n<li> Izquierdo delso Miguel \u00e1ngel (vocal)<\/li>\n<li>sergi Erill saez (vocal)<\/li>\n<li>joan Albanell mestres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Farre Valle En esta tesis se estudia como el \u00f3rgano en el que se implanta el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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