{"id":15976,"date":"2002-08-03T00:00:00","date_gmt":"2002-08-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-actividad-ae2-y-de-la-expresion-del-correspondiente-gen-en-colangiocitos-de-pacientes-con-cirrosis-biliar-primaria\/"},"modified":"2002-08-03T00:00:00","modified_gmt":"2002-08-03T00:00:00","slug":"estudio-de-la-actividad-ae2-y-de-la-expresion-del-correspondiente-gen-en-colangiocitos-de-pacientes-con-cirrosis-biliar-primaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-actividad-ae2-y-de-la-expresion-del-correspondiente-gen-en-colangiocitos-de-pacientes-con-cirrosis-biliar-primaria\/","title":{"rendered":"Estudio de la actividad ae2 y de la expresi\u00f3n del correspondiente gen en colangiocitos de pacientes con cirrosis biliar primaria"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Saida Melero Iba\u00f1ez <\/strong><\/h2>\n<p>La cirrosis biliar primaria (cbp) es una enfermedad colest\u00e1sica cr\u00f3nica que progresa hacia la cirrosis. Se caracteriza por una reacci\u00f3n inflamatoria en los conductos biliares intrahep\u00e1ticos que va obstruyendo y destruy\u00e9ndolos progresivamente. El origen de la enfermedad es desconocido y se considera multifactorial. Uno de los factores que intervienen en la etiopatogenia de la cbp es el fen\u00f3meno de la autoinmunidad. Recientemente, se ha observado una alteraci\u00f3n en la secreci\u00f3n biliar de bicarbonato en los pacientes con cbp. Dos sistemas de transporte en colangiocitos, el cloro\/bicarbonato independiente de sodio (actividad ae) y el sodio\/prot\u00f3n (actividad nhe) participan el transporte \u00e1cido-base biliar. El principal objetivo de este trabajo es discernir si la alteraci\u00f3n en el transporte de bicarbonato en pacientes con cbp es intr\u00ednseca a los colangiocitos de estos pacientes o no. As\u00ed pues, se midieron las actividades ae y nhe en colangiocitos humanos tanto en condiciones basales como bajo el efecto de sus correspondientes agonistas, camp y atp respectivamente. Los colangiocitos se asilaron inmunomagn\u00e9ticamente y se cultivaron de explantes hep\u00e1ticos provenientes de pacientes con cbp (n=9), de individuos sanos (n=6) y de pacientes con hepatopat\u00edas diversas a cbp (n=8). Adem\u00e1s, se cultivaron colangiocitos de biopsias percut\u00e1neas provenientes de 12 pacientes con cbp, de 8 individuos sanos y de 9 pacientes con otras hepatopat\u00edas. Se observaron unos valores de actividad ae significativamente menores en colangiocitos de pacientes con cbp cultivados de biopsias percut\u00e1neas, respecto a aquellos de individuos normales y de pacientes con otras hepatopat\u00edas. adem\u00e1s, mientras que el camp produc\u00eda un aumento significativo en la actividad ae, respecto a sus valores basales, en colangiocitos de individuos normales y de pacientes con hepatopat\u00edas no cbp, \u00e9ste no se observa en colangiocitos de pacientes con cbp. Este resultado fue observ<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la actividad ae2 y de la expresi\u00f3n del correspondiente gen en colangiocitos de pacientes con cirrosis biliar primaria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la actividad ae2 y de la expresi\u00f3n del correspondiente gen en colangiocitos de pacientes con cirrosis biliar primaria <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Saida Melero Iba\u00f1ez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Francisco Medina Cabrera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>mario Strazzabosco (vocal)<\/li>\n<li>Ana Barber carcano (vocal)<\/li>\n<li>arancha Arrazola zabaleta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Saida Melero Iba\u00f1ez La cirrosis biliar primaria (cbp) es una enfermedad colest\u00e1sica cr\u00f3nica que progresa hacia la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,17749],"tags":[50685,50686,15059,50683,50684,50682],"class_list":["post-15976","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-navarra","tag-ana-barber-carcano","tag-arancha-arrazola-zabaleta","tag-jesus-m-prieto-valtuena","tag-juan-francisco-medina-cabrera","tag-mario-strazzabosco","tag-saida-melero-ibanez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15976","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=15976"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/15976\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=15976"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=15976"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=15976"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}