{"id":16019,"date":"2002-12-03T00:00:00","date_gmt":"2002-12-03T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-funcional-del-gen-ehs1-de-schizosaccharomyces-pombe\/"},"modified":"2002-12-03T00:00:00","modified_gmt":"2002-12-03T00:00:00","slug":"caracterizacion-funcional-del-gen-ehs1-de-schizosaccharomyces-pombe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/caracterizacion-funcional-del-gen-ehs1-de-schizosaccharomyces-pombe\/","title":{"rendered":"Caracterizaci\u00f3n funcional del gen ehs1+ de schizosaccharomyces pombe"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Carnero Gonz\u00e1lez Elena M. <\/strong><\/h2>\n<p>El mutante ehs-1 fue aislado en una b\u00fasqueda de mutantes hipersensibles a equinocandina y calcofluor, dos antif\u00fangicos que interfieren en la bios\u00edntesis de la pared celular.Ehs1-1 presenta adem\u00e1s, un fenotipo de lisis a altas temperaturas que se corrige en presencia de estabilizadores osm\u00f3ticos.Ehs1-1, mayor sensibilidad al tratamiento con enzimas que degradan la pared celular y una peque\u00f1a descompensaci\u00f3n en los pol\u00edmeros que componen la pared celular. la prote\u00edna ehs1p muestra un cierto parecido con mid1p de s.Cerevisiae, una prote\u00edna asociada a la membrana plasm\u00e1tica y es necesaria para la toma de calcio durante el proceso de conjugaci\u00f3n. Bas\u00e1ndonos en este parecido hemos visto que ehs1+ est\u00e1 implicado en la acumulaci\u00f3n intracelular de calcio. Un incremento de la concentraci\u00f3n externa de calcio suprime todos los fenotipos asociados a la falta del gen ehs1+, sugiriendo que los defectos asociados a la integridad celular en el mutante ehs1+ estar\u00edan relacionados con defectos en el metabolismo del calcio. En s.Cerevisiae se ha propuesto que mid1p junto con la prote\u00edna cch1p formar\u00edan parte de un canal de calcio. cch1p presenta un gran parecido con las subunidades alfa1 de diferentes canales de calcio dependientes de voltaje identificados en c\u00e9lulas de mam\u00edferos. nosotros hemos identificado una prote\u00edna similar a cch1p en s.Pombe (spcch1p). curiosamente los mutantes ehs1*, spcch1* y ehs1*spcch1* muestran el mismo grado de sensibilidad a equinocandina lo que sugiere que ehs1p y spcch1p podr\u00edan formar parte de un canal de calcio que se hallar\u00eda conservado a lo largo de la evoluci\u00f3n. Hemos observado una interacci\u00f3n g\u00e9nica entre ehs1+ y pck2+ un hom\u00f3logo a pkc de mam\u00edferos.Pck2+ suprime todos los fenotipos asociados al mutante ehs1-1. Nuestros resultados sugieren que ehs1p formar\u00edan parte de un canal de calcio que participar\u00eda en el mantenimiento de la integridad celular junto con la prote\u00edna quinasa pck2p.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n funcional del gen ehs1+ de schizosaccharomyces pombe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n funcional del gen ehs1+ de schizosaccharomyces pombe <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Carnero Gonz\u00e1lez Elena M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Yolanda Sanchez Martin<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Mar\u00eda  del pilar Perez gonzalez <\/li>\n<li> Montero zoccola M\u00aa teresa (vocal)<\/li>\n<li>Javier \u00e1lvarez nombela (vocal)<\/li>\n<li>rosa Aligue alemany (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carnero Gonz\u00e1lez Elena M. El mutante ehs-1 fue aislado en una b\u00fasqueda de mutantes hipersensibles a equinocandina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,36483,35,984,978,278,9386],"tags":[50810,50813,9869,50812,50814,50811],"class_list":["post-16019","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-biologia-molecular","category-ciencias-de-la-vida","category-levaduras","category-metabolismo-microbiano","category-microbiologia","category-salamanca","tag-carnero-gonzalez-elena-m","tag-javier-alvarez-nombela","tag-maria-del-pilar-perez-gonzalez","tag-montero-zoccola-ma-teresa","tag-rosa-aligue-alemany","tag-yolanda-sanchez-martin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16019","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16019"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16019\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16019"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16019"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16019"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}