{"id":16032,"date":"2018-03-09T09:03:27","date_gmt":"2018-03-09T09:03:27","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-de-la-beta-catenina-en-el-carcinoma-epidermoide-de-esofago-estudio-cla%c2%adnico-patologico-y-analisis-de-la-supervivencia\/"},"modified":"2018-03-09T09:03:27","modified_gmt":"2018-03-09T09:03:27","slug":"expresion-de-la-beta-catenina-en-el-carcinoma-epidermoide-de-esofago-estudio-cla%c2%adnico-patologico-y-analisis-de-la-supervivencia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-de-la-beta-catenina-en-el-carcinoma-epidermoide-de-esofago-estudio-cla%c2%adnico-patologico-y-analisis-de-la-supervivencia\/","title":{"rendered":"Expresi\u00f3n de la beta-catenina en el carcinoma epidermoide de es\u00f3fago: estudio cl\u00ednico-patol\u00f3gico y an\u00e1lisis de la supervivencia"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco JavierDe Castro Carpe\u00f1o <\/strong><\/h2>\n<p>En el presente estudio se ha analizado la expresi\u00f3n de la beta-catenina en 39 casos de carcinoma epidermoide de es\u00f3fago que hab\u00edan sido sometidos a un proceso digan\u00f3stico y terap\u00e9utico homog\u00e9neo, de acuerdo a un protocolo multidisciplinario entre los servicios de oncolog\u00eda m\u00e9dica, anatom\u00eda patol\u00f3gica y cirug\u00eda general del hospital universitario de la paz. Los patrones de expresi\u00f3n de la beta-catenina han sido correlacionados con par\u00e1metros cl\u00ednicos como el estadio y localizaci\u00f3n del tumor, el consumo de alcohol y tabaco, el estado general y la respuesta a la quimioterapia; con par\u00e1metros patol\u00f3gicos, como el grado de diferenciaci\u00f3n del humor y la expresi\u00f3n de las prote\u00ednas p53, cadherina-e, bcl-2 y ki-67. Adem\u00e1s, todos los par\u00e1metros han sido analizados con respecto a la supervivencia y, en un grupo de casos, se ha secuenciado el ex\u00f3n 3 del gen de la beta-catenina (ctnnb1) donde se han descrito mutaciones que pueden ocasionar expresi\u00f3n an\u00f3mala de la beta-catenina en diferentes tumores.  se ha encontrado expresi\u00f3n nuclear de la beta-catenina en 7 de los 39 casos analizados, lo que supone el primer carcinoma de tipo epidermoide donde se describe este patr\u00f3n. Estos 7 casos de expresi\u00f3n nuclear ten\u00edan una asociaci\u00f3n estad\u00edsticamente significativa con la expresi\u00f3n de la bcl-2 y la ausencia de la p53. Sin embargo, el estudio del ex\u00f3n 3 del gen ctnnb1 no evidenci\u00f3 mutaciones por lo que se sugiere que debe haber otros mecanismos implicados.  aunque no se ha alcanzado una significaci\u00f3n estad\u00edstica, en los pacientes con expresi\u00f3n nuclear de la beta-catenina se observaron una serie de rasgos cl\u00ednicos y patol\u00f3gicos relevantes en cuanto a la localizaci\u00f3n del tumor, respuesta al tratamiento, supervivencia, expresi\u00f3n de la cadherina-e y de ki-67. Todo ello sugiere que la alteraci\u00f3n de la expresi\u00f3n de la beta-catenina podr\u00eda estar implicada en la carcinog\u00e9nesis de un subgrupo de carcinomas epidermoides de es<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n de la beta-catenina en el carcinoma epidermoide de es\u00f3fago: estudio cl\u00ednico-patol\u00f3gico y an\u00e1lisis de la supervivencia<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n de la beta-catenina en el carcinoma epidermoide de es\u00f3fago: estudio cl\u00ednico-patol\u00f3gico y an\u00e1lisis de la supervivencia <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco JavierDe Castro Carpe\u00f1o <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel G\u00f3nzalez Bar\u00f3n<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Nistal mart\u00edn de serrano <\/li>\n<li>Jos\u00e9 Palacios calvo (vocal)<\/li>\n<li>Francisco Aranlich fern\u00e1ndez (vocal)<\/li>\n<li>Antonio Colmenarejo rubio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco JavierDe Castro Carpe\u00f1o En el presente estudio se ha analizado la expresi\u00f3n de la beta-catenina en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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