{"id":16036,"date":"2018-03-09T09:03:28","date_gmt":"2018-03-09T09:03:28","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/nanoparta%c2%adculas-a-base-del-copola%c2%admero-de-metil-vinil-eter-y-anhidrido-maleico-como-formas-bioadhesivas-para-la-administracion-oral-de-farmacos\/"},"modified":"2018-03-09T09:03:28","modified_gmt":"2018-03-09T09:03:28","slug":"nanoparta%c2%adculas-a-base-del-copola%c2%admero-de-metil-vinil-eter-y-anhidrido-maleico-como-formas-bioadhesivas-para-la-administracion-oral-de-farmacos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/nanoparta%c2%adculas-a-base-del-copola%c2%admero-de-metil-vinil-eter-y-anhidrido-maleico-como-formas-bioadhesivas-para-la-administracion-oral-de-farmacos\/","title":{"rendered":"Nanopart\u00edculas a base del copol\u00edmero de metil vinil \u00e9ter y anhidrido maleico como formas bioadhesivas para la administraci\u00f3n oral de f\u00e1rmacos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pau Arb\u00f3s Vila <\/strong><\/h2>\n<p>El objetivo de este trabajo ha consistido en el desarrollo y evaluaci\u00f3n de nuevas formas bioadhesivas a base del copol\u00edmero de metil vinil \u00e9ter y anh\u00eddrido maleico para la administraci\u00f3n a trav\u00e9s de mucosas de f\u00e1rmacos con bajas biodisponibilidades. Las formas farmac\u00e9uticas escogidas fueron nanopart\u00edculas y conjugados.  en la preparaci\u00f3n de las nanopart\u00edculas (np) se emple\u00f3 el m\u00e9todos de desolvataci\u00f3n del disolvente. Con el objeto de aumentar su estabilidad en medios acuosos se procedi\u00f3 a modificar las propiedades de la superficie de np mediante reticulaci\u00f3n con diversas cantidades de 1,3-diaminopropano (dp) (formulaciones d5-np, d10-np y d30-np), recubriendo con alb\u00famina s\u00e9rica bovina (bsa-np), o realizando ambos procesos (bd-np). Por otro lado, los conjugados se obtuvieron mediante la uni\u00f3n covalente de la lectina sambucus nigra a la superficie de np (sna-np).  posteriormente, se evalu\u00f3 el potencial bioadhesivo de las formulaciones. la interacci\u00f3n del pol\u00edmero con la mucosa fue mucho mayor cuando se formul\u00f3 como nanopart\u00edculas (np) que bajo forma solubilizada en agua. La reticulaci\u00f3n con dp disminuy\u00f3 significativamente la adhesi\u00f3n a la mucosa, y al mismo tiempo, aument\u00f3 la velocidad de vaciado g\u00e1strico e intestinal. Por otro lado, el recubrimiento con alb\u00famina de las part\u00edculas reticuladas (bd-np permiti\u00f3 aumentar la intensidad del fen\u00f3meno bioadhesivo y disminuir el tr\u00e1nsito gastrointestinal de las part\u00edculas. Bsa-np present\u00f3 una elevada afinidad adhesiva por la mucosa g\u00e1strica. As\u00ed mismo se observ\u00f3 un retraso en la adhesividad m\u00e1xima de sna-np, aunque el potencial bioadhesivo fue del mismo orden que las part\u00edculas control (d30-np).  finalmente, se evalu\u00f3 la capacidad de estos veh\u00edculos para administrar f\u00e1rmacos con metabolismo presist\u00e9mico, utilizando 5-fluorouridina (formulaciones bsa-np, np y bd-np). Los niveles de f\u00e1rmaco analizados en orina y tejidos demostraron que solamente bsa-np<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Nanopart\u00edculas a base del copol\u00edmero de metil vinil \u00e9ter y anhidrido maleico como formas bioadhesivas para la administraci\u00f3n oral de f\u00e1rmacos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Nanopart\u00edculas a base del copol\u00edmero de metil vinil \u00e9ter y anhidrido maleico como formas bioadhesivas para la administraci\u00f3n oral de f\u00e1rmacos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pau Arb\u00f3s Vila <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 13\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Manuel Irache Garreta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas Larralde <\/li>\n<li>franz Gabor (vocal)<\/li>\n<li>joaquin Giraldez deiro (vocal)<\/li>\n<li> Otero espinar Francisco Javier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pau Arb\u00f3s Vila El objetivo de este trabajo ha consistido en el desarrollo y evaluaci\u00f3n de nuevas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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