{"id":16075,"date":"2018-03-09T09:03:31","date_gmt":"2018-03-09T09:03:31","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/diseno-elaboratorio-y-optimizacion-de-un-sistema-de-liberacion-contratada-de-didanosina-para-el-tratamiento-del-sida\/"},"modified":"2018-03-09T09:03:31","modified_gmt":"2018-03-09T09:03:31","slug":"diseno-elaboratorio-y-optimizacion-de-un-sistema-de-liberacion-contratada-de-didanosina-para-el-tratamiento-del-sida","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/diseno-elaboratorio-y-optimizacion-de-un-sistema-de-liberacion-contratada-de-didanosina-para-el-tratamiento-del-sida\/","title":{"rendered":"Dise\u00f1o, elaboratorio y optimizaci\u00f3n de un sistema de liberaci\u00f3n contratada de didanosina para el tratamiento del sida"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carla S\u00e1nchez-lafuente L\u00f3pez <\/strong><\/h2>\n<p>Los objetivos propuestos en la presente tesis doctoral est\u00e1n orientados hacia la obtenci\u00f3n de un nuevo medicamento de didanosina (ddl) que pueda ser incluido en el arsenal terap\u00e9utico del tratamiento de personas infectadas por el virus de la inmunodeficiencia humana adquirida. Se pretende contribuir, de este modo, a una mejora, aunque sea leve, de la calidad de vida de millones de pacientes seropositivos.  en la presente tesis doctoral se abarca, en primer lugar, la preformulaci\u00f3n de ddl. As\u00ed, se concluye que el f\u00e1rmaco satisface todos los requisitos necesarios para poder ser vehiculizado en sistemas de liberaci\u00f3n controlada.  en segundo lugar, la aplicaci\u00f3n de las t\u00e9cnicas propias del dise\u00f1o experimental permiti\u00f3 desarrolar un sistema matricial inerte de liberaci\u00f3n controlada con dosis elevadas de ddl (libremente soluble en agua), que proporciona un mecanismo difusional durante el proceso de liberaci\u00f3n, combinando pol\u00edmeros metacr\u00edlicos y etilcelul\u00f3sico.  el proceso de recubrimiento empleado para evitar la liberaci\u00f3n de ddl g\u00e1strico se basa en la inmersi\u00f3n del sistema matricial en una dispersi\u00f3n acuosa parcialmente neutralizada de eudragit l30d-55 y 3% p\/p de trietilcitrato como plastificante. Este procedimiento impide la liberaci\u00f3n del ddl en medio g\u00e1strico y proporciona una liberaci\u00f3n controlada en medio intestinal.  a modo de recapitulaci\u00f3n se puede concluir se\u00f1alando que el dise\u00f1o experimental aplicado al campo farmac\u00e9utico, concretamente en la formulaci\u00f3n farmac\u00e9utica, ha resultado ser una herramienta muy \u00fatil. Con ella se ha desarrollado de forma racional un sistema de liberaci\u00f3n programada de dosis elevada de didanosina capaz de proteger eficazmente al f\u00e1rmaco en medio g\u00e1strico y de proporcionar su liberaci\u00f3n controlada en medio intestinal durante un per\u00edodo m\u00ednimo de 8 horas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Dise\u00f1o, elaboratorio y optimizaci\u00f3n de un sistema de liberaci\u00f3n contratada de didanosina para el tratamiento del sida<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Dise\u00f1o, elaboratorio y optimizaci\u00f3n de un sistema de liberaci\u00f3n contratada de didanosina para el tratamiento del sida <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carla S\u00e1nchez-lafuente L\u00f3pez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Rabasco Alvarez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: adela Mart\u00edn villodr\u00e9 <\/li>\n<li> De uaal robert marius (vocal)<\/li>\n<li>angela Mura paola (vocal)<\/li>\n<li>Jos\u00e9 Almeida Antonio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carla S\u00e1nchez-lafuente L\u00f3pez Los objetivos propuestos en la presente tesis doctoral est\u00e1n orientados hacia la obtenci\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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