{"id":16081,"date":"2018-03-09T09:03:32","date_gmt":"2018-03-09T09:03:32","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-por-el-estres-de-la-funcion-gastrointestinal-implicacion-fisiologica-y-modulacion-farmacologica\/"},"modified":"2018-03-09T09:03:32","modified_gmt":"2018-03-09T09:03:32","slug":"regulacion-por-el-estres-de-la-funcion-gastrointestinal-implicacion-fisiologica-y-modulacion-farmacologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/regulacion-por-el-estres-de-la-funcion-gastrointestinal-implicacion-fisiologica-y-modulacion-farmacologica\/","title":{"rendered":"Regulaci\u00f3n por el estr\u00e9s de la funci\u00f3n gastrointestinal: implicaci\u00f3n fisiol\u00f3gica y modulaci\u00f3n farmacol\u00f3gica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eugenia Garc\u00eda Zaragoza <\/strong><\/h2>\n<p>Este estudio supone la continuaci\u00f3n de una l\u00ednea de investigaci\u00f3n consolidada en el campo de la farmacolog\u00eda digestiva, que ha cristalizado en la caracterizaci\u00f3n del no como mediador central de diversas funciones gastrointestinales. el presente trabajo, pretende profundizar en el origen (humoral o nervioso) y mecanismos centrales de acci\u00f3n, de un reflejo nervioso mediado por el no, y que es puesto en marcha por el organismo en respuesta al estr\u00e9s. observaciones previas, sugieren que la s\u00edntesis central de no desempe\u00f1a un papel fundamental en la inhibici\u00f3n de la secreci\u00f3n \u00e1cida g\u00e1strica observada en dos modelos experimentales de estr\u00e9s som\u00e1tico: la administraci\u00f3n de il-1 y de dosis subs\u00e9pticas de endotoxina. En el presente trabajo, la administraci\u00f3n en la cisterna magna de agonistas y antagonistas del glutamato, de inhibidores de la nos y de inhibidores y an\u00e1logos de producto de la gcs, demuestra la implicaci\u00f3n de la v\u00eda central end\u00f3gena del glutamato \/no\/gmpc en la hiposecreci\u00f3n g\u00e1strica mediada por el estr\u00e9s. Paralelamente, la medida de la actividad nos en el tronco de enc\u00e9falo, ha permitido identificar a la isoforma nos neuronal como la responsable de dicha s\u00edntesis nitr\u00e9gica observada. La participaci\u00f3n del snc en nuestro reflejo se ha confirmado mediante la determinaci\u00f3n de la inmunoreactividad para la prote\u00edna fos, que ha mostrado una clara activaci\u00f3n nueronal de los n\u00facleos del dvc del tronco del enc\u00e9falo en nuestras condiciones de entotoxemia leve. Por \u00faltimo, se demuestra que este reflejo r\u00e1pido hiposecretor, forma parte de la v\u00eda neuronal de actuaci\u00f3n de la endotoxina sobre fibras nerviosas aferentes vagales, siendo por lo tanto independiente de la activaci\u00f3n cl\u00e1sica de la v\u00eda humoral de la inflamaci\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulaci\u00f3n por el estr\u00e9s de la funci\u00f3n gastrointestinal: implicaci\u00f3n fisiol\u00f3gica y modulaci\u00f3n farmacol\u00f3gica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulaci\u00f3n por el estr\u00e9s de la funci\u00f3n gastrointestinal: implicaci\u00f3n fisiol\u00f3gica y modulaci\u00f3n farmacol\u00f3gica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eugenia Garc\u00eda Zaragoza <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Esplugues Mota Juan  Vicente<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Morcillo s\u00e1nchez esteban j. <\/li>\n<li>josep Mar\u00eda Pique badia (vocal)<\/li>\n<li>Miguel Bixquert jimenez (vocal)<\/li>\n<li>belen Beltran niclos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eugenia Garc\u00eda Zaragoza Este estudio supone la continuaci\u00f3n de una l\u00ednea de investigaci\u00f3n consolidada en el campo [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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