{"id":16126,"date":"2018-03-09T09:03:36","date_gmt":"2018-03-09T09:03:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sobrecarga-de-hierro-en-la-hepatitis-cronica-c-correlacion-con-las-mutaciones-del-gen-hfe-y-analisis-de-los-aspectos-etiologicos-cla%c2%adnicos-y-terapeuticos\/"},"modified":"2018-03-09T09:03:36","modified_gmt":"2018-03-09T09:03:36","slug":"sobrecarga-de-hierro-en-la-hepatitis-cronica-c-correlacion-con-las-mutaciones-del-gen-hfe-y-analisis-de-los-aspectos-etiologicos-cla%c2%adnicos-y-terapeuticos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sobrecarga-de-hierro-en-la-hepatitis-cronica-c-correlacion-con-las-mutaciones-del-gen-hfe-y-analisis-de-los-aspectos-etiologicos-cla%c2%adnicos-y-terapeuticos\/","title":{"rendered":"Sobrecarga de hierro en la hepatitis cr\u00f3nica c: correlaci\u00f3n con las mutaciones del gen hfe y an\u00e1lisis de los aspectos etiologicos, cl\u00ednicos y terap\u00e9uticos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Luis Ignacio Fern\u00e1ndez Salazar <\/strong><\/h2>\n<p>La evoluci\u00f3n de la hepatitis cr\u00f3nica por el vhc (hcc) y su respuesta al tratamiento antiviral es variable y depende de diversos factores entre los que se puede incluir a la sobrecarga de hierro (sch). La sch puede ser debida a mutaciones del gen hfe de la hemocromatosis o secundaria a otras enfermedades entre las que se encuentran las hepatopat\u00edas cr\u00f3nicas.  objetivos  determinar la preValencia de sch entre los pacientes con hcc, sus perfiles bioqu\u00edmicos, las causas o factores asociados y las consecuencias a nivel anal\u00edtico, morfol\u00f3gico (ecograf\u00eda, biopsia hep\u00e1tica) y de respuesta al tratamiento de la sch en la hcc.  material y m\u00e9todo  estudio retrospectivo de 303 historias de pacientes con hcc, determinaci\u00f3n mediante t\u00e9cnica de pcr de las mutaciones del gen hfe (c282y, h63d) en 20 pacientes con hcc y elevaci\u00f3n del istf y\/o ferritina. Se define sch como elevaci\u00f3n de istf y ferretina. Estudio y comparaci\u00f3n de los asepctos epidemiol\u00f3gicos, valores de hemograma y bioqu\u00edmica en sangre, aspectos virol\u00f3gicos, ecograf\u00eda e histolog\u00eda as\u00ed como de la respuesta al tratamiento antiviral en funci\u00f3n de la presencia de sch, elevaci\u00f3n de ferritina, del istf o de la presencia de hierro hep\u00e1tico.  resultados y discusi\u00f3n  el 11% de los pacientes tiene sch, el 31% tiene elevaci\u00f3n de la feritina, el 19% elevaci\u00f3n del istf y el 9% dep\u00f3sito de hierro hep\u00e1tico, esto coincide con otros trabajos realizados. Ferritina e istf no son buenos predictores del dep\u00f3sito de hierro hep\u00e1tico. La sch se asocia a mayor edad, ingesti\u00f3n de alcohol, genotipo 1b del vhc, enfermedad metab\u00f3lica asociada (hiperglucemia, hiperlipidemia, hipertensi\u00f3n arterial). No se identifica ning\u00fan portador de la mutaci\u00f3n c282y, la tasa de heterocig\u00f3ticos para h63d es 35% y los homocig\u00f3ticos es 10%. La sch supone menor cifra de plaquetas, mayor citolisis y colestasis y peor funci\u00f3n hepatocelular, lo que implica mayor gravedad de la hepatopat\u00eda. Adem\u00e1s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sobrecarga de hierro en la hepatitis cr\u00f3nica c: correlaci\u00f3n con las mutaciones del gen hfe y an\u00e1lisis de los aspectos etiologicos, cl\u00ednicos y terap\u00e9uticos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sobrecarga de hierro en la hepatitis cr\u00f3nica c: correlaci\u00f3n con las mutaciones del gen hfe y an\u00e1lisis de los aspectos etiologicos, cl\u00ednicos y terap\u00e9uticos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Luis Ignacio Fern\u00e1ndez Salazar <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ricardo Moreno Otero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Pajares Garc\u00eda Jos\u00e9 m. <\/li>\n<li>teresa Arranz santos (vocal)<\/li>\n<li>agustin Caro paton gomez (vocal)<\/li>\n<li>tom\u00e1s \u00e1lvarez gabo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Luis Ignacio Fern\u00e1ndez Salazar La evoluci\u00f3n de la hepatitis cr\u00f3nica por el vhc (hcc) y su respuesta [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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