{"id":16171,"date":"2018-03-09T09:03:39","date_gmt":"2018-03-09T09:03:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/relaciones-entre-cretenses-y-otros-pueblos-mediterraneos-segun-los-genes-hla-y-las-culturas\/"},"modified":"2018-03-09T09:03:39","modified_gmt":"2018-03-09T09:03:39","slug":"relaciones-entre-cretenses-y-otros-pueblos-mediterraneos-segun-los-genes-hla-y-las-culturas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/relaciones-entre-cretenses-y-otros-pueblos-mediterraneos-segun-los-genes-hla-y-las-culturas\/","title":{"rendered":"Relaciones entre cretenses y otros pueblos mediterr\u00e1neos seg\u00fan los genes hla y las culturas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eduardo G\u00f3mez Casado <\/strong><\/h2>\n<p>El sistema principal de histocompatibilidad humano (hla) es un conjunto de genes localizados en el brazo corto del cromosoma 6 y codifican para una serie de prote\u00ednas denominadas \u00abmol\u00e9culas o ant\u00edgenos hla\u00bb, que se expresan en la mayor\u00eda de las c\u00e9lulas del organismo. Su funci\u00f3n principal es la presentaci\u00f3n de fragmentos antig\u00e9nicos al receptor del linfocito t (tcr) con el fin de iniciar una respuesta inmune frente a los pat\u00f3genos y los propio alterado (tumores). Las caracter\u00edsticas principales del sistema hla son 3: es polig\u00e9nico, altamente polim\u00f3rfico, y presenta desequilibrio de ligamiento. Estas caracter\u00edsticas son la base de la aplicaci\u00f3n del estudio del sistema hla a la gen\u00e9tica comparada de poblaciones; los grupos poblacionales muestran alelos hla caracter\u00edsticos, variaciones de frecuencias al\u00e9licas y haplotipos espec\u00edficos, que sirven para observar el grado de emparentamiento de las poblaciones y correlacionarlo con la historia y las migraciones.  en el presente estudio se seleccionaron 135 individuos sanos no relacionados cuyos antepasados hubieran vivido en creta durante al menos tres generaciones. se obtuvo adn gen\u00f3mico por m\u00e9todos est\u00e1ndar a partir de sangre perif\u00e9rica. se realiz\u00f3 la reacci\u00f3n en cadena de las polimerasa (pcr) para los loci hla-a, -b, -drb1, -dqa1, y -dqb1. La determinaci\u00f3n de los alelos hla en cada individuo se realiz\u00f3 por t\u00e9cnicas de oligotipaje directo, reverso y de secuenciaci\u00f3n. Se calcularon las frecuencias al\u00e9licas para cada locus y los haplotipos caracter\u00edsticos. Los datos obtenidos fueron comparados con los de otras poblaciones mediterr\u00e1neas (caucasoides, norteafricanas) incluyendo a la poblaci\u00f3n macedonia y tres poblaciones griegas.  las distancias gen\u00e9ticas, dendrogramas y an\u00e1lisis de correspondencia obtenidos muestran que los cretenses son muy parecidos a los mediterr\u00e1neos orientales (macedonios en especial, turcos, libaneses, armenios, jud\u00edos), y tambi\u00e9n los occi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Relaciones entre cretenses y otros pueblos mediterr\u00e1neos seg\u00fan los genes hla y las culturas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Relaciones entre cretenses y otros pueblos mediterr\u00e1neos seg\u00fan los genes hla y las culturas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eduardo G\u00f3mez Casado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Arnaiz Villena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  jos\u00e9 Picazo de la garza <\/li>\n<li>Mar\u00eda  soledad Mesa santurino (vocal)<\/li>\n<li>Jos\u00e9 Luis Vicario  moreno (vocal)<\/li>\n<li>f\u00e9lix Garc\u00eda s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eduardo G\u00f3mez Casado El sistema principal de histocompatibilidad humano (hla) es un conjunto de genes localizados en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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