{"id":16185,"date":"2018-03-09T09:03:41","date_gmt":"2018-03-09T09:03:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-anala%c2%adtico-del-dano-por-isquemia-reperfusion-en-un-modelo-experimental-de-trasplante-cardiaco-evaluacion-del-papel-citoprotector-de-la-trimetazidina\/"},"modified":"2018-03-09T09:03:41","modified_gmt":"2018-03-09T09:03:41","slug":"estudio-anala%c2%adtico-del-dano-por-isquemia-reperfusion-en-un-modelo-experimental-de-trasplante-cardiaco-evaluacion-del-papel-citoprotector-de-la-trimetazidina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-anala%c2%adtico-del-dano-por-isquemia-reperfusion-en-un-modelo-experimental-de-trasplante-cardiaco-evaluacion-del-papel-citoprotector-de-la-trimetazidina\/","title":{"rendered":"Estudio anal\u00edtico del da\u00f1o por isquemia-reperfusi\u00f3n en un modelo experimental de trasplante cardiaco. evaluaci\u00f3n del papel citoprotector de la trimetazidina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Evaristo Castedo Mejuto <\/strong><\/h2>\n<p>Objetivos  el fallo primario del injerto es una de las primeras causas de mortalidad precoz tras el trasplante cardiaco (tc). El da\u00f1o por isquemia-reperfusi\u00f3n mediado por los radicales libres (rl) es uno de los factores que m\u00e1s consistentemente se han implicado en su etiopatogenia. En este estudio se trat\u00f3 de evaluar el posible efecto citoprotector de la trimetazidina (tmz) en la prevenci\u00f3n del da\u00f1o inducido por los rl durante el tc,  material y m\u00e9todos  se realizaron 21 tc ortot\u00f3picos con circulaci\u00f3n extracorp\u00f3rea en cerdos de la raza landrace x large-white 18-25 kg. De peso, empleando a otro grupo de 21 cerdos de similares caracter\u00edsticas como donantes. Dividimos los experimentos en 2 grupos: 11 animales sirvieron como grupo control (grupo a) y los otros 10 se sometieron a tratamiento con tmz (grupo b). El f\u00e1rmaco se administr\u00f3 en 3 momentos a lo largo del tc: en la cardioplegia empleada para parar el coraz\u00f3n donante (tmz), 10-5m), como pretratamiento endovenoso en el receptor 10 minutos antes de pinzar la aorta (tmz, 2,5 mg\/kg), y como parte de la cardioplegia administrada en el receptor antes de despinzar la aorta (tmz, 10-5 m). Se tomaron muestras de sangre del seno coronario del receptor en 3 momentos: basal, antes de empezar el tc, en la m\u00e1xima isquemia, antes de despinzar la aorta y a los 30 minutos de reperfusi\u00f3n. el nivel de citoprotecci\u00f3n mioc\u00e1rdica se estudi\u00f3 determinado el nivel de creatinfosfoquinasa (cpk), lactato deshidrogenasa (ldh), malonildialdehido (mda) como marcador del nivel de peroxidaci\u00f3n lip\u00eddica y de varios antioxidantes: alfa-tocoferol, retinol, glutation peroxidasa (gsh-px), glutation reductasa, super\u00f3xido dismutasa y estado de antioxidantes totales (eat).  resultados  no hubo diferencias significativas entre los grupos por lo que respecta al tiempo de isquemia, tiempo de circulaci\u00f3n extracorp\u00f3rea y necesidad de f\u00e1rmacos inotr\u00f3picos. La tolerancia a la administraci\u00f3n de tmz fue<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio anal\u00edtico del da\u00f1o por isquemia-reperfusi\u00f3n en un modelo experimental de trasplante cardiaco. evaluaci\u00f3n del papel citoprotector de la trimetazidina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio anal\u00edtico del da\u00f1o por isquemia-reperfusi\u00f3n en un modelo experimental de trasplante cardiaco. evaluaci\u00f3n del papel citoprotector de la trimetazidina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Evaristo Castedo Mejuto <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 21\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Segovia Escudero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Castillo olivares Jos\u00e9 Luis <\/li>\n<li>Jes\u00fas Herreros gonzalez (vocal)<\/li>\n<li>valent\u00edn Cuervas mons (vocal)<\/li>\n<li>angel Luis Fernandez gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Evaristo Castedo Mejuto Objetivos el fallo primario del injerto es una de las primeras causas de mortalidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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