{"id":16192,"date":"2018-03-09T09:03:41","date_gmt":"2018-03-09T09:03:41","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/hmgcoa-reductasa-y-reproduccion-en-blattella-germanica-l-dictyoptera-blattellidae\/"},"modified":"2018-03-09T09:03:41","modified_gmt":"2018-03-09T09:03:41","slug":"hmgcoa-reductasa-y-reproduccion-en-blattella-germanica-l-dictyoptera-blattellidae","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/hmgcoa-reductasa-y-reproduccion-en-blattella-germanica-l-dictyoptera-blattellidae\/","title":{"rendered":"Hmgcoa reductasa y reproducci\u00f3n en blattella germanica (l.) (dictyoptera, blattellidae)"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Zapata Preguezuelo <\/strong><\/h2>\n<p>El estudio de la v\u00eda del mevalonato en insectos tiene un gran inter\u00e9s ya que estos organismos no producen colesterol mediante esta v\u00eda, y son un sistema id\u00f3neo para estudiar la regulaci\u00f3n de la hmgcoa reductasa (enzima limitante de la ruta metab\u00f3lica) por otros metabolitos de esta v\u00eda. Adem\u00e1s esta v\u00eda metab\u00f3lica se ha relacionado con procesos relacionados con la reproducci\u00f3n de las cucarachas como la vitelog\u00e9nesis. As\u00ed se plantearon los siguientes objetivos:  1,- caracterizar la expresi\u00f3n, a nivel de mrna, prote\u00edna y actividad enzim\u00e1tica de la hmgcoa reductasa en el cuerpo graso, el ovario y el embri\u00f3n de blattella germanica.  2,- estudiar el papel de la v\u00eda del mevalonato en la reproducci\u00f3n de b. Germanica, utilizando inhibidores de la mhgcoa reductasa como la compactina y la fluvastatina.  3,- estudiar la posible aplicaci\u00f3n como insecticidas de la compactina, la fluvastatina y otros an\u00e1logos.  la evoluci\u00f3n de los niveles de mrna, de prote\u00edna y de actividad hmgcoa reductasa en el cuerpo graso muestra que esta enzima se regula a nivel de la transcripci\u00f3n, la traducci\u00f3n y a nivel post-traduccional. La administraci\u00f3n de fluvastatina y compactina induce una p\u00e9rdida de la actividad de la enzima en el cuerpo graso que correlaciona con una disminuci\u00f3n de la prote\u00edna. esta menor cantidad de la prote\u00edna de la enzima no comporta menores niveles de su mrna lo que sugiere que las estatinas hab\u00edan inhibido la traducci\u00f3n, o m\u00e1s probablemente que la prote\u00edna hmgcoa reductasa se degrada m\u00e1s r\u00e1pidamente en cuerpos grasos tratados con estos compuestos. La administraci\u00f3n de fluvastatina y compactina no modifica los niveles de vitelogenina en la hemolinfa 24 horas despu\u00e9s del tratamiento. Sin embargo s\u00ed disminuye la incorporaci\u00f3n de vitelogenina al ovario transcurridas 96 horas despu\u00e9s del tratamiento. ello sugiere que se necesita una inhibici\u00f3n prolongada de la enzima para inhibir procesos importantes en la rep<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Hmgcoa reductasa y reproducci\u00f3n en blattella germanica (l.) (dictyoptera, blattellidae)<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Hmgcoa reductasa y reproducci\u00f3n en blattella germanica (l.) (dictyoptera, blattellidae) <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Zapata Preguezuelo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Xavier Belles Ros<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquim Guti\u00e9rrez fruit\u00f3s <\/li>\n<li>Mar\u00eda  dolors Piulachs baga (vocal)<\/li>\n<li>marina Blas esteban (vocal)<\/li>\n<li>david Mart\u00edn casacuberta (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Zapata Preguezuelo El estudio de la v\u00eda del mevalonato en insectos tiene un gran inter\u00e9s ya [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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