{"id":16238,"date":"2018-03-09T09:03:45","date_gmt":"2018-03-09T09:03:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modelizacion-farmacocinetica-farmacodinamica-de-respuestas-no-continuas\/"},"modified":"2018-03-09T09:03:45","modified_gmt":"2018-03-09T09:03:45","slug":"modelizacion-farmacocinetica-farmacodinamica-de-respuestas-no-continuas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modelizacion-farmacocinetica-farmacodinamica-de-respuestas-no-continuas\/","title":{"rendered":"Modelizaci\u00f3n farmacocinetica\/farmacodinamica de respuestas no-continuas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Javier Rapado Santaolalla <\/strong><\/h2>\n<p>El modelado pk\/pd bajo la aproximaci\u00f3n poblacional se est\u00e1 convirtiendo en una herramienta de gran uso en el desarrollo de nuevos medicamentos. la inclusi\u00f3n del modelado pk\/pd lleva a la caracterizaci\u00f3n del perfil cl\u00ednico de nuevos f\u00e1rmacos en las fases temprenas de desarrollo, excluyendo candidatos no prometedores cuando la inversi\u00f3n es relativamente baja a favor de candidatos con alta probabilidad de \u00e9xito.  por otra parte, la respuesta farmacol\u00f3gica es compleja en t\u00e9rminos de medida y significancia cl\u00ednica, presentando adem\u00e1s una alta variabilidad, lo que la hace muy dif\u00edcil de interpretar. Las compa\u00f1\u00edas farmac\u00e9uticas suelen estar m\u00e1s interesadas en resultados cl\u00ednicos que en marcadores surrogados. estos resultados cl\u00ednicos casi nunca se registran como respuestas cont\u00ednuas, lo que resulta en una necesidad de m\u00e9todos alternativos de an\u00e1lisis para su incorporaci\u00f3n en el modelado pk\/pd.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modelizaci\u00f3n farmacocinetica\/farmacodinamica de respuestas no-continuas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modelizaci\u00f3n farmacocinetica\/farmacodinamica de respuestas no-continuas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Javier Rapado Santaolalla <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Ignacio Fernandez De Troconiz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Martinez lanao <\/li>\n<li>Mar\u00eda del carmen Dios vi\u00e9itez (vocal)<\/li>\n<li>Manuel j Barbanoj rodr\u00edguez (vocal)<\/li>\n<li>norberto Aguirre garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Javier Rapado Santaolalla El modelado pk\/pd bajo la aproximaci\u00f3n poblacional se est\u00e1 convirtiendo en una herramienta de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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