{"id":16250,"date":"2018-03-09T09:03:46","date_gmt":"2018-03-09T09:03:46","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/osteoporosis-en-la-cirrosis-hepatica-avanzada-evolucion-tras-trasplante-hepatico-estudio-de-los-mecanismos-de-osteopenia-y-su-correlacion-con-la-sa%c2%adntesis-de-igf-i\/"},"modified":"2018-03-09T09:03:46","modified_gmt":"2018-03-09T09:03:46","slug":"osteoporosis-en-la-cirrosis-hepatica-avanzada-evolucion-tras-trasplante-hepatico-estudio-de-los-mecanismos-de-osteopenia-y-su-correlacion-con-la-sa%c2%adntesis-de-igf-i","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/osteoporosis-en-la-cirrosis-hepatica-avanzada-evolucion-tras-trasplante-hepatico-estudio-de-los-mecanismos-de-osteopenia-y-su-correlacion-con-la-sa%c2%adntesis-de-igf-i\/","title":{"rendered":"Osteoporosis en la cirrosis hep\u00e1tica avanzada. evoluci\u00f3n tras trasplante hep\u00e1tico. estudio de los mecanismos de osteopenia y su correlaci\u00f3n con la s\u00edntesis de igf-i"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 M. Pego Reigosa <\/strong><\/h2>\n<p>Introducci\u00f3n  la ostodistrofia hep\u00e1tica (oh) es la enfermedad metab\u00f3lica \u00f3sea asociada a las enfermedades hepatobiliares cr\u00f3nicas (ehc). El tratamiento \u00faltimo de estas enfermedades es, en muchos casos, el trasplante hep\u00e1tico (th). se ha estudiado muy poco el efecto del th sobre el metabolismo del hueso. existe un campo abierto a la investigaci\u00f3n de m\u00faltiples aspectos de la osteoporosis (op) asociada a las ehc y la repercusi\u00f3n del th sobre la misma.  objetivos  1,- evaluar la incidencia de op y fracturas vetebrales en pacientes con cirrosis hep\u00e1tica avanzada (cha) en lista de espera de th y en los ya trasplantados.  2,- evaluar el efecto del th en la evoluci\u00f3n de la op y su repercusi\u00f3n cl\u00ednica (fracturas vertebrales).  3,- evaluar factores predictivos de una masa \u00f3sea (mo) disminuida y de fractura vertebral.  4,- investigar los mecanismos favorecedores de la op en estos pacientes.  5,- valorar la implicaci\u00f3n del factor de crecimiento similar a la insulina (igf-i) y sus prote\u00ednas ligadoras bp1 y bp3 en la mo de estos enfermos.  pacientes y m\u00e9todos  complementaron el estudios 46 pacientes diagn\u00f3sticados de cha. Se distribuyeron en dos grupos:  grupo a (10 pacientes en lista de espera de th)  grupo b (36 pacientes ya sometidos a th como consecuencia de una cha).  este grupo se dividi\u00f3, en funci\u00f3n de los meses transcurridos desde la fecha de th hasta su inclusi\u00f3n en el estudio, en tres subgrupos: b1 (&lt;12 meses), b2 (12-24 meses) y b3 (&gt;24 meses). A todos ellos se les realiz\u00f3 una completa evaluaci\u00f3n en dos momentos del estudio: t1 (momento de inclusi\u00f3n en el estudio) y t2 (un a\u00f1o despu\u00e9s de t1). Esta evaluaci\u00f3n consisti\u00f3 en:  1,- una valoraci\u00f3n cl\u00ednica (datos del paciente, de la hepatopat\u00eda, del th, dosis de inmunosupresores).  2,- una valoraci\u00f3n anal\u00edtica: ordinaria, par\u00e1metros espec\u00edficos del metabolismo \u00f3seo (calcio y f\u00f3sforo s\u00e9ricos, calcio en orina de 24 horas, mol\u00e9cula intact<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Osteoporosis en la cirrosis hep\u00e1tica avanzada. evoluci\u00f3n tras trasplante hep\u00e1tico. estudio de los mecanismos de osteopenia y su correlaci\u00f3n con la s\u00edntesis de igf-i<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Osteoporosis en la cirrosis hep\u00e1tica avanzada. evoluci\u00f3n tras trasplante hep\u00e1tico. estudio de los mecanismos de osteopenia y su correlaci\u00f3n con la s\u00edntesis de igf-i <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 M. Pego Reigosa <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge  Augusto Quiroga Vilas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pilar Civeira murillo <\/li>\n<li>arturo Gonzalez quintela (vocal)<\/li>\n<li>daniel Casanova rituerto (vocal)<\/li>\n<li>Francisco Javier Salvador rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 M. Pego Reigosa Introducci\u00f3n la ostodistrofia hep\u00e1tica (oh) es la enfermedad metab\u00f3lica \u00f3sea asociada a las [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139,17749,877],"tags":[51442,10546,14910,18372,51441,17764],"class_list":["post-16250","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","category-navarra","category-reumatologia","tag-arturo-gonzalez-quintela","tag-daniel-casanova-rituerto","tag-francisco-javier-salvador-rodriguez","tag-jorge-augusto-quiroga-vilas","tag-jose-m-pego-reigosa","tag-pilar-civeira-murillo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16250"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16250\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16250"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16250"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}