{"id":16256,"date":"2018-03-09T09:03:47","date_gmt":"2018-03-09T09:03:47","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-accion-proinflamatoria-de-la-angiotensina-ii-y-su-posible-modulacion-papel-de-angiotensina-ii-en-disfunciones-endoteliales\/"},"modified":"2018-03-09T09:03:47","modified_gmt":"2018-03-09T09:03:47","slug":"estudio-de-la-accion-proinflamatoria-de-la-angiotensina-ii-y-su-posible-modulacion-papel-de-angiotensina-ii-en-disfunciones-endoteliales","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-accion-proinflamatoria-de-la-angiotensina-ii-y-su-posible-modulacion-papel-de-angiotensina-ii-en-disfunciones-endoteliales\/","title":{"rendered":"Estudio de la acci\u00f3n proinflamatoria de la angiotensina ii y su posible modulaci\u00f3n. papel de angiotensina ii en disfunciones endoteliales"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Angeles Alavarez Ribelles <\/strong><\/h2>\n<p>La acumulaci\u00f3n leucocitaria es una caracter\u00edstica de los primeros estudios de la lesi\u00f3n ateroscler\u00f3tica, de infarto agudo de miocardio y de enfermedades renales de diversa etiolog\u00eda. Receptores para angiotensina-ii (ang-ii) han sido hallados en monocitos y ang-ii pueden promover la activaci\u00f3n y adhesi\u00f3n de estas c\u00e9lulas. Este proceso podr\u00eda desencadenar o perpetuar el da\u00f1o endotelial asociado a aterosclerosis en hipertensi\u00f3n. Los resultados de nuestro estudio demuestran que ang-ii, a dosis subvasoconstrictoras y fisiol\u00f3gicas, presenta propiedades proinflamatorias in vivo a nivel agudo; en concreto, produce acumulaci\u00f3n leucocitaria en v\u00e9nulas de la microcirculaci\u00f3n mesent\u00e9rica de la rata a trav\u00e9s del aumento de expresi\u00f3n de p-selectina endotelial, efecto mediado mediante interacci\u00f3n con sus receptores espec\u00edficos at1 y at2. Sin embargo, el hecho m\u00e1s relevante de este trabajo es que al administrar ang-ii de forma subagua se produce adhesi\u00f3n leucocitaria no s\u00f3lo a nivel venular sino tambi\u00e9n a nivel arteriolar, hecho que podr\u00eda relacionarla directamente con el inicio de la lesi\u00f3n ateroscler\u00f3tica. Las respuestas leucocitarias inducidas por ang-ii a nivel agudo pueden se moduladas por antioxidantes,por compuestos capaces de aumentar los niveles de ampc, gmpc y por estr\u00f3genos. Adem\u00e1s, en circunstancias de disfunci\u00f3n endotelial producida por falta de vasodilatadores como no o pgi2, se produce una r\u00e1pida respuesta inflamatoria la cual est\u00e1 mediada por ang-ii ya que el tratamiento con el antagonista selectivo frente al receptor at1 inhibi\u00f3 la infiltraci\u00f3n leucocitaria y los cambios hemodin\u00e1micos debidos a la carancia de estos vasodilatadores.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la acci\u00f3n proinflamatoria de la angiotensina ii y su posible modulaci\u00f3n. papel de angiotensina ii en disfunciones endoteliales<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la acci\u00f3n proinflamatoria de la angiotensina ii y su posible modulaci\u00f3n. papel de angiotensina ii en disfunciones endoteliales <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Angeles Alavarez Ribelles <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/03\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda Jes\u00fas Sanz Ferrando<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Morcillo s\u00e1nchez esteban j. <\/li>\n<li>pedro Lorenzo fern\u00e1ndez (vocal)<\/li>\n<li> Estrella ariguel Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Juan  Luis Tamargo men\u00e9ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Angeles Alavarez Ribelles La acumulaci\u00f3n leucocitaria es una caracter\u00edstica de los primeros estudios de la lesi\u00f3n ateroscler\u00f3tica, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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