{"id":16284,"date":"2002-04-04T00:00:00","date_gmt":"2002-04-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-oxido-nitrico-sobre-el-efecto-de-aspirina-ticlopidina-y-clopidogrel-en-la-interaccion-plaqueta-pared-vascular\/"},"modified":"2002-04-04T00:00:00","modified_gmt":"2002-04-04T00:00:00","slug":"influencia-del-oxido-nitrico-sobre-el-efecto-de-aspirina-ticlopidina-y-clopidogrel-en-la-interaccion-plaqueta-pared-vascular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-del-oxido-nitrico-sobre-el-efecto-de-aspirina-ticlopidina-y-clopidogrel-en-la-interaccion-plaqueta-pared-vascular\/","title":{"rendered":"Influencia del oxido nitrico sobre el efecto de aspirina, ticlopidina y clopidogrel en la interacci\u00f3n plaqueta-pared vascular"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda  Monsalud Arrebola Ramirez <\/strong><\/h2>\n<p>Los f\u00e1rmacos antiagregantes plaquetarios se utilizan en la prevenci\u00f3n de las enfermedades tromboemb\u00f3licas, siendo \u00e1cido acetilsalic\u00edlico (aas), ticlopidina y clopidogrel los m\u00e1s utilizados en la pr\u00e1ctica cl\u00ednica diaria. recientemente se ha demostrado que la producci\u00f3n de \u00f3xido n\u00edtrico (no) leucocitario es importante para explicar el efecto antitromb\u00f3tico del aas.  teniendo en cuenta que el no se produce fundamentalmente en las c\u00e9lulas endoteliales de la pared vascular y que no se conoce la relaci\u00f3n de ticlopidina y clopidogrel con dicho no, nos planteamos el presente estudio con los siguientes objetivos:  1,- valorar qu\u00e9 efecto producen estos compuestos en la formaci\u00f3n de no leucocitario y endotelial.  2,- analizar c\u00f3mo se modfiica el efecto antiplaquetario de estos compuestos en ausencia de no.  el estudio se ha realizado in vitro y se valoraron las siguientes t\u00e9cnicas de estudio: agregometria plaquetaria en sangre total, producci\u00f3n plaquetaria de tromboxano, producci\u00f3n de no en neutr\u00f3filos y en c\u00e9lulas endoteliales humanas en cultivo, perfusi\u00f3n sangu\u00ednea sobre matrices subendoteliales producidas por c\u00e9lulas endoteliales humanas en cultivo, analizando morfol\u00f3gicamente la interacci\u00f3n plaqueta-subendotelio, en ausencia o presencia de una capa de c\u00e9lulas endoteliales. Como inhibidor de la producci\u00f3n de no se utiliz\u00f3 lname.  los tres f\u00e1rmacos estudiados inhibieron la agregaci\u00f3n plaquetaria e incrementaron la producci\u00f3n de no, siendo clopidogrel el que mayor efecto produjo a nivel de c\u00e9lulas endoteliales. En ausencia de no, aas redujo su efecto antiagregante, no as\u00ed ticlopidina y clopidogrel.  en las perfusiones sangu\u00edneas, al bloquear la producci\u00f3n de no, se redujo el efecto antitromb\u00f3tico de aas y de ticopidina, no afect\u00e1ndose el efecto de clopidogrel sobre la itneracci\u00f3n plaqueta-pared vascular.  en resumen, el mayor efecto antiagregante plaquetario de clopiodogrel, as\u00ed como el mantenimiento<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del oxido nitrico sobre el efecto de aspirina, ticlopidina y clopidogrel en la interacci\u00f3n plaqueta-pared vascular<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del oxido nitrico sobre el efecto de aspirina, ticlopidina y clopidogrel en la interacci\u00f3n plaqueta-pared vascular <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda  Monsalud Arrebola Ramirez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 04\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Pedro De La Cruz Cort\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Zaragoza garcia <\/li>\n<li>pablo Salinas s\u00e1nchez (vocal)<\/li>\n<li> Fern\u00e1ndez iriarte Mar\u00eda  del carmen (vocal)<\/li>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez correa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Monsalud Arrebola Ramirez Los f\u00e1rmacos antiagregantes plaquetarios se utilizan en la prevenci\u00f3n de las enfermedades tromboemb\u00f3licas, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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