{"id":16313,"date":"2002-05-04T00:00:00","date_gmt":"2002-05-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-fisiopatologico-de-la-trombocitopenia-en-la-cirrosis-hepatica-el-papel-de-la-trombopoyetina\/"},"modified":"2002-05-04T00:00:00","modified_gmt":"2002-05-04T00:00:00","slug":"estudio-fisiopatologico-de-la-trombocitopenia-en-la-cirrosis-hepatica-el-papel-de-la-trombopoyetina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-fisiopatologico-de-la-trombocitopenia-en-la-cirrosis-hepatica-el-papel-de-la-trombopoyetina\/","title":{"rendered":"Estudio fisiopatol\u00f3gico de la trombocitopenia en la cirrosis hep\u00e1tica. el papel de la trombopoyetina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Raquel Rios Fernandez <\/strong><\/h2>\n<p>Introducci\u00f3n  la trombocitopenia es una complicaci\u00f3n frecuente de la cirrosis hep\u00e1tica. a pesar de que se le ha atribuido distintos factores como la insuficiencia hep\u00e1tica, la hipertensi\u00f3n portal y el secuestro espl\u00e9nico, no se ha estudiado la influencia relativa de cada uno de ellos en su intensidad.  objetivos  determinar qu\u00e9 factores influyen independientemente en la intensidad de la trombocitopenia de los pacientes con cirrosis; comparar los niveles de trombopoyetina de un grupo con cirrosis y plaquetopenia con un grupo control, y estudiar c\u00f3mo se modifican dichos factores y los niveles de trombopoyetina tras la colocaci\u00f3n de tips, embolizaci\u00f3n espl\u00e9nica y trasplante hep\u00e1tico.  material y m\u00e9todos  se realiz\u00f3 un estudio multivariante en una poblaci\u00f3n de 224 pacientes y se valor\u00f3 el efecto del tratamiento en 90 de ellos.  resultados  los niveles trombopoyetina son significtivamente m\u00e1s bajos en los pacientes con cirrosis y trombocitopenia que en los controles sanos (p&lt;0,001). En los cirr\u00f3ticos los niveles circulantes de trombopoyetina no dependen del recuento plaquetario sino del tama\u00f1o del bazo (p=0,387, p=0,046). Tras la embolizaci\u00f3n espl\u00e9nica y el trasplante hep\u00e1tico se incrementan dichos niveles y se recupera la relaci\u00f3n fisiol\u00f3gica con el recuento plaquetario.  conclusiones  la trombocitopenia en los pacientes con cirrosis no s\u00f3lo se debe a una menor funci\u00f3n de s\u00edntesis hep\u00e1tica sino tambi\u00e9n a una mayor degradaci\u00f3n de trombopoyetina por las plaquetas secuestradas por el bazo, de tal manera que a medida que aumenta el secuestro de plaquetas en el bazo se interfiere la acci\u00f3n de la trombopoyetina sobre la megacariopoyesis de la m\u00e9dula \u00f3sea.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio fisiopatol\u00f3gico de la trombocitopenia en la cirrosis hep\u00e1tica. el papel de la trombopoyetina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio fisiopatol\u00f3gico de la trombocitopenia en la cirrosis hep\u00e1tica. el papel de la trombopoyetina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Raquel Rios Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Navarra<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 05\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>acebo Sangro G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jes\u00fas m. Prieto valtue\u00f1a <\/li>\n<li>agust\u00edn Albillos g\u00f3mez (vocal)<\/li>\n<li>agustin Caro paton gomez (vocal)<\/li>\n<li>Jos\u00e9 Antonio Paramo fernandez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Raquel Rios Fernandez Introducci\u00f3n la trombocitopenia es una complicaci\u00f3n frecuente de la cirrosis hep\u00e1tica. a pesar de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,491,139,17749],"tags":[51612,51613,9694,15059,18182,51611],"class_list":["post-16313","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-gastroenterologia","category-medicina-interna","category-navarra","tag-acebo-sangro-gomez","tag-agustin-albillos-gomez","tag-agustin-caro-paton-gomez","tag-jesus-m-prieto-valtuena","tag-jose-antonio-paramo-fernandez","tag-raquel-rios-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16313","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16313"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16313\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16313"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16313"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16313"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}