{"id":16362,"date":"2002-11-04T00:00:00","date_gmt":"2002-11-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/analisis-de-la-expresion-del-perfil-de-citoquinas-en-biopsias-de-glandulas-salivales-menores-de-pacientes-con-el-sa%c2%adndrome-de-sja%c2%b6gren-primario\/"},"modified":"2002-11-04T00:00:00","modified_gmt":"2002-11-04T00:00:00","slug":"analisis-de-la-expresion-del-perfil-de-citoquinas-en-biopsias-de-glandulas-salivales-menores-de-pacientes-con-el-sa%c2%adndrome-de-sja%c2%b6gren-primario","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/analisis-de-la-expresion-del-perfil-de-citoquinas-en-biopsias-de-glandulas-salivales-menores-de-pacientes-con-el-sa%c2%adndrome-de-sja%c2%b6gren-primario\/","title":{"rendered":"An\u00e1lisis de la expresi\u00f3n del perfil de citoquinas en biopsias de gl\u00e1ndulas salivales menores de pacientes con el s\u00edndrome de sj\u00c1\u00b6gren primario"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ant\u00f3n-peter Reth <\/strong><\/h2>\n<p>El objetivo de esta tesis doctoral fue el an\u00e1lisis de la expresi\u00f3n del rna de citoquinas en la gl\u00e1ndula salival menor de pacientes con el s\u00edndrome de sj\u00ed\u00b6ren primario (ssp).  se ha analizado 42 biopsias de gl\u00e1ndula salival menor de pacientes con el ssp, 12 con un ssp probable y 30 con un ssp definido. El an\u00e1lisis del rna total se realiz\u00f3 por normalizaci\u00f3n con retrotranscripci\u00f3n y reacci\u00f3n en cadena de polimerasa (rt-pcr), utilizando oligo-dt como sonda para la rt y sondas espec\u00edficas para la amplificaci\u00f3n de il-2, ifn-gamma, il-12, il-18, il-4, il-10, tgf-beta y tnf-alfa.  los resultados fueron analizado en relaci\u00f3n al:  1,- diagn\u00f3stico de ssp probable (12 pacientes) y ssp defindio (30 pacientes), siguiendo los criterios diagn\u00f3sticos europeos.  2,- grado de afectaci\u00f3n histol\u00f3gica de acuerdo con la clasificaci\u00f3n de chisholm y mason.  3,- tiempo de evoluci\u00f3n cl\u00ednica, desde el inicio de la sintomatolog\u00eda cl\u00ednica hasta el momento de realizar la biopsia de gl\u00e1ndula salival menor, realizando un corte arbitrario a los 12 meses de evoluci\u00f3n cl\u00ednica.  esta tesis doctoral demuestra la presencia de un patr\u00f3n predominante th1 de expresi\u00f3n linfocitario en la gl\u00e1ndula salival menor de pacientes con la ssp, con la detecci\u00f3n de il-2 y i-fngamma; y de los inductores este patr\u00f3n th1, il-12 y il-18 en la mayor\u00eda de los pacientes con el ssp. No se detecto il-4 en ninguna de las muestras estudiadas, descartando la presencia th2.  tambi\u00e9n se detecto en la mayor\u00eda de las muestras il-10, tgf-beta y tnf-alfa, citoquinas pro inflamatorias. No se detecto diferencias estad\u00edsticamente significativas en la comparci\u00f3n del perfil de citoquinas entre los pacientes con un ssp definido y probable, ni en relaci\u00f3n con el grado de afectaci\u00f3n histol\u00f3gica ni en relaci\u00f3n a la formaci\u00f3n o no de focos de infiltraci\u00f3n linfocitario.  en cambio, hay un incremento en la expresi\u00f3n de la il-2 y del ifn-gamma, con significado estad\u00edsti<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>An\u00e1lisis de la expresi\u00f3n del perfil de citoquinas en biopsias de gl\u00e1ndulas salivales menores de pacientes con el s\u00edndrome de sj\u00c1\u00b6gren primario<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 An\u00e1lisis de la expresi\u00f3n del perfil de citoquinas en biopsias de gl\u00e1ndulas salivales menores de pacientes con el s\u00edndrome de sj\u00c1\u00b6gren primario <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ant\u00f3n-peter Reth <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Coll Daroca<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: miquel Vilardell tarres <\/li>\n<li>Miguel Lopez botet arbona (vocal)<\/li>\n<li>joan Pedro-botet montoya (vocal)<\/li>\n<li>jospe Font franco (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ant\u00f3n-peter Reth El objetivo de esta tesis doctoral fue el an\u00e1lisis de la expresi\u00f3n del rna de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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