{"id":16396,"date":"2002-12-04T00:00:00","date_gmt":"2002-12-04T00:00:00","guid":{"rendered":""},"modified":"2002-12-04T00:00:00","modified_gmt":"2002-12-04T00:00:00","slug":"recuento-y-caracterizacion-inmunofenotipica-de-celulas-progenitoras-hempatopoyeticas-cd34-en-medula-osea-y-sangre-periferica-movilizada-implicaciones-cla%c2%adnicas-en-el-trasplante-autologo-y-aloge","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/recuento-y-caracterizacion-inmunofenotipica-de-celulas-progenitoras-hempatopoyeticas-cd34-en-medula-osea-y-sangre-periferica-movilizada-implicaciones-cla%c2%adnicas-en-el-trasplante-autologo-y-aloge\/","title":{"rendered":"Recuento y caracterizaci\u00f3n inmunofenotipica de c\u00e9lulas progenitoras hempatopoyeticas cd34+ en m\u00e9dula \u00f3sea y sangre perif\u00e9rica movilizada: implicaciones cl\u00ednicas en el trasplante aut\u00f3logo y alog\u00e9nico de sangre perif\u00e9rica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Men\u00e9ndez Bujan <\/strong><\/h2>\n<p>En relaci\u00f3n con los aspectos metodol\u00f3gicos empleados para el recuento de cph cd34+ y de sus subpoblaciones mediante citometr\u00eda de flujo puede usarse cualquier soluci\u00f3n lisante de hemat\u00edes siempre que esta no vaya seguida de lavados celulares, ya que estos inducen perdidas selectivas de c\u00e9lulas cd34+. Si es imprescindible llevar a cabo un lavado celular debemos emplear soluciones de lisis libres de fijador. Las combinaciones de acmc cd90\/cd133\/cd38\/cd34 y cd71\/cd13\/cd45\/cd34 nos permiten identificar de manera fiable y reproducible los progenitores m\u00e1s inmaduros, mielomonoc\u00ed\u00edticos, eritroides y linfoides b.  el r\u00e9gimen de movilizaci\u00f3n empleado tiene una clara influencia sobre la distribuci\u00f3n de las distintas subpoblaciones cd34+ y cd34- en  los productos de af\u00e9resis. As\u00ed, en n\u00fameros relativos el g-csf administrado de forma aislada es el m\u00e1s eficaz en la movilizaci\u00f3n de progenitores inmaduros mientras que cuando se emplea en conjunci\u00f3n con ciclofosfamida favorece la movilizaci\u00f3n de progenitores eritroides. En n\u00fameros absolutos, el protocolo g-csf+ccf+scf es el m\u00e1s eficaz tanto en la movilizaci\u00f3n del n\u00famero total de cd34+ como de sus subpoblaciones.  la composici\u00f3n de inoculo a infundir influye en la evoluci\u00f3n cl\u00ednica del transplante. As\u00ed, tanto en el trasplante aut\u00f3logo como alog\u00e9nico los progenitores mielomonoc\u00edticos tienen un valor predicitvo adicional respecto al n\u00famero global de cd34+ infundido, en lo que a la recuperaci\u00f3n de neutr\u00f3filso en sp se refiere. Adem\u00e1s, en el trasplante aut\u00f3logo el n\u00famero de linfocitos t cd4+ infundidos condiciona la incidencia de infecciones mientras que una dosis de c\u00e9lulas cd34+ mielomonociticas &gt;3.5x 10(6)\/kg de peso aumenta significativamente el riesgo de desarrollar eich post-trasplante alog\u00e9nico no mieloablativo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Recuento y caracterizaci\u00f3n inmunofenotipica de c\u00e9lulas progenitoras hempatopoyeticas cd34+ en m\u00e9dula \u00f3sea y sangre perif\u00e9rica movilizada: implicaciones cl\u00ednicas en el trasplante aut\u00f3logo y alog\u00e9nico de sangre perif\u00e9rica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Recuento y caracterizaci\u00f3n inmunofenotipica de c\u00e9lulas progenitoras hempatopoyeticas cd34+ en m\u00e9dula \u00f3sea y sangre perif\u00e9rica movilizada: implicaciones cl\u00ednicas en el trasplante aut\u00f3logo y alog\u00e9nico de sangre perif\u00e9rica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Men\u00e9ndez Bujan <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Alberto Orfao De Matos Correia E Vale<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda Moraleda jim\u00e9nez <\/li>\n<li>felipe Luis Prosper cardoso (vocal)<\/li>\n<li>\u00e1lvaro Urbano ispiz\u00faa (vocal)<\/li>\n<li>Jos\u00e9 Antonio P\u00e9rez sim\u00f3n (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Men\u00e9ndez Bujan En relaci\u00f3n con los aspectos metodol\u00f3gicos empleados para el recuento de cph cd34+ y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,218,139,9386],"tags":[38197,18255,25781,51846,24983,51845],"class_list":["post-16396","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-hematologia","category-medicina-interna","category-salamanca","tag-alvaro-urbano-ispizua","tag-felipe-luis-prosper-cardoso","tag-jose-alberto-orfao-de-matos-correia-e-vale","tag-jose-antonio-perez-simon","tag-jose-maria-moraleda-jimenez","tag-pablo-menendez-bujan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16396","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16396"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16396\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16396"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16396"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16396"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}