{"id":16404,"date":"2002-12-04T00:00:00","date_gmt":"2002-12-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-participacion-del-tnfalfa-y-las-prostaglandinas-en-las-alteraciones-digestivas-producidas-por-endotoxinas-en-la-oveja\/"},"modified":"2002-12-04T00:00:00","modified_gmt":"2002-12-04T00:00:00","slug":"estudio-de-la-participacion-del-tnfalfa-y-las-prostaglandinas-en-las-alteraciones-digestivas-producidas-por-endotoxinas-en-la-oveja","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-participacion-del-tnfalfa-y-las-prostaglandinas-en-las-alteraciones-digestivas-producidas-por-endotoxinas-en-la-oveja\/","title":{"rendered":"Estudio de la participaci\u00f3n del tnfalfa y las prostaglandinas en las alteraciones digestivas producidas por endotoxinas en la oveja"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Guerrero Lindner <\/strong><\/h2>\n<p>El objetivo general de este trabajo ha sido el estudio de los mecanismos neuro-inmunol\u00f3gicos y endocrinos responsables de la fiebre y de las alteraciones de la motilidad gastrointestinal de la oveja inducidas por una endotoxina bacteriana: el lipopolisac\u00e1rido (lps) de escherichia coli. Para ello se han realizado estudios in vivo mediante la t\u00e9cnica de electromiograf\u00eda, con implantaci\u00f3n cr\u00f3nica de electrodos en la pared del tracto digestivo, as\u00ed como registros de la actividad mec\u00e1nica in vitro en ba\u00f1o de \u00f3rganos, en preparaciones de m\u00fasculo liso gastrointestinal ovino. En ambos casos, la adquisici\u00f3n y tratamiento de datos se ha realizado a trav\u00e9s de ordenador.  la administraci\u00f3n intravenosa (iv) de lps produce un aumento de la temperatura corporal. Al mismo tiempo , inhibe la actividad mioel\u00e9ctrica del antro, duodeno y yeyuno e incrementa la frecuencia de las fases iii del complejo mioel\u00e9ctrico migratorio (cmm). Estos efectos son reproducidos de manera dosis-dependiente por la administraci\u00f3n intracerebroventricular (icv) de las citocinas tnfalfa e il-1beta. El tratamiento previo icv con el receptor soluble del tnf (etanercept) bloquea los efectos producidos por el tnfalfa e inhibe parcialmente los inducidos por lps sin modificar los de la il-1beta. en contraste con su administraci\u00f3n icv, la inyecci\u00f3n iv de tnfalfa y de su receptor soluble no altera ninguno de los par\u00e1metros estudiados. Ello sugiere que el lps act\u00faa a trav\u00e9s de la liberaci\u00f3n central de tnfalfa. por otra parte, la indometacina (inhibidor de la s\u00edntesis de prostaglandinas) bloquea los efectos inducidos por el lps y por el tnfalfa cuando \u00e9sta se administra por v\u00eda central, pero no por v\u00eda perif\u00e9rica. Adem\u00e1s, la inyecci\u00f3n icv de la prostaglandina e2 (pge2) produce efectos similares a los del lps, mientras que su administraci\u00f3n iv no altera la temperatura corporal y s\u00f3lo produce una inhibici\u00f3n transitoria de la motilidad gastrointestinal. estos re<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la participaci\u00f3n del tnfalfa y las prostaglandinas en las alteraciones digestivas producidas por endotoxinas en la oveja<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la participaci\u00f3n del tnfalfa y las prostaglandinas en las alteraciones digestivas producidas por endotoxinas en la oveja <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Guerrero Lindner <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Zaragoza<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Angel Plaza Carrion<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: albino Garc\u00eda sacrist\u00e1n <\/li>\n<li>patrocinio Vergara esteras (vocal)<\/li>\n<li>M\u00aa divina Murillo lopez de silanes (vocal)<\/li>\n<li>Jos\u00e9 ignacio San rom\u00e1n Garc\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Guerrero Lindner El objetivo general de este trabajo ha sido el estudio de los mecanismos neuro-inmunol\u00f3gicos [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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