{"id":16413,"date":"2002-12-04T00:00:00","date_gmt":"2002-12-04T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/propiedades-fotofa%c2%adsicas-dinamica-conformacional-e-interaccion-con-microtubulos-de-derivados-fluorescentes-de-taxol-utilizando-espectroscopia-laser-de-polarizacion-en-el-picosegundo\/"},"modified":"2002-12-04T00:00:00","modified_gmt":"2002-12-04T00:00:00","slug":"propiedades-fotofa%c2%adsicas-dinamica-conformacional-e-interaccion-con-microtubulos-de-derivados-fluorescentes-de-taxol-utilizando-espectroscopia-laser-de-polarizacion-en-el-picosegundo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/fisica\/propiedades-fotofa%c2%adsicas-dinamica-conformacional-e-interaccion-con-microtubulos-de-derivados-fluorescentes-de-taxol-utilizando-espectroscopia-laser-de-polarizacion-en-el-picosegundo\/","title":{"rendered":"Propiedades fotof\u00edsicas, din\u00e1mica conformacional e interacci\u00f3n con microt\u00fabulos de derivados fluorescentes de taxol, utilizando espectroscopia l\u00e1ser de polarizaci\u00f3n en el picosegundo"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Olga Ca\u00f1adas Benito <\/strong><\/h2>\n<p>El taxol es un f\u00e1rmaco antitumoral ampliamente empleado en la cl\u00ednica actual, que inhibe la divisi\u00f3n celular mediante la supresi\u00f3n de la inestabilidad din\u00e1mica de los mcirot\u00fabulos.  mediante la utilizaci\u00f3n de las t\u00e9cnicas de espectroscop\u00eda de fluorescencia y polarizaci\u00f3n de fluorescencia en estado estacionario y con resoluci\u00f3n temporal de picosegundos se ha estudiado la interacci\u00f3n de unos derivados fluorescentes de taxol con los microt\u00fabulos. Para ello, se ha estudiado en primer lugar la fotof\u00edsica y el comportamiento hidrodin\u00e1mico de dichos taxoides en disoluci\u00f3n y se ha desarrollado un nuevo m\u00e9todo, basado en el an\u00e1lisis simult\u00e1neo de magnitudes espectrosc\u00f3picas estacionarias (absorci\u00f3n, intensidad de fluorescencia) y cin\u00e9ticas (vidas medias de fluorescenica), que ha permitido determinar la constante de equilibrio de disociaci\u00f3n del grupo fenol del clorante de flutax-1.  los estudios hidrodin\u00e1micos realizados ha proporcionado una descripci\u00f3n detallada de la flexibilidad segmental y conformaci\u00f3n de estos compuestos en los tampones utilizados.  para el estudio de la interacci\u00f3n de los taxoides fluorescentes con las suspensiones de microt\u00fabulos se han desarrollado t\u00e9cnicas de vidas medias y despolarizaci\u00f3n de fluorescencia inducida por l\u00e1ser, as\u00ed como m\u00e9todos de an\u00e1lisis de la superposici\u00f3n de procesos difusivo-rotacionales.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Propiedades fotof\u00edsicas, din\u00e1mica conformacional e interacci\u00f3n con microt\u00fabulos de derivados fluorescentes de taxol, utilizando espectroscopia l\u00e1ser de polarizaci\u00f3n en el picosegundo<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Propiedades fotof\u00edsicas, din\u00e1mica conformacional e interacci\u00f3n con microt\u00fabulos de derivados fluorescentes de taxol, utilizando espectroscopia l\u00e1ser de polarizaci\u00f3n en el picosegundo <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Olga Ca\u00f1adas Benito <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 12\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Lilllo Villalobos M. Pilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: guillermo Orellana moraleda <\/li>\n<li>german Rivas caballero (vocal)<\/li>\n<li>carmen reyes Mateo mart\u00ednez (vocal)<\/li>\n<li>Rafael Giraldo suarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Olga Ca\u00f1adas Benito El taxol es un f\u00e1rmaco antitumoral ampliamente empleado en la cl\u00ednica actual, que inhibe [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17426,651,199,560],"tags":[51886,51885,5613,51884,51883,51887],"class_list":["post-16413","post","type-post","status-publish","format-standard","hentry","category-alcala","category-espectroscopia-molecular-en-quimica-fisica","category-fisica","category-quimica-fisica","tag-carmen-reyes-mateo-Martinez","tag-german-rivas-caballero","tag-guillermo-orellana-moraleda","tag-lilllo-villalobos-m-pilar","tag-olga-canadas-benito","tag-rafael-giraldo-suarez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16413"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16413\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}