{"id":16420,"date":"2018-03-09T09:04:00","date_gmt":"2018-03-09T09:04:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mecanismos-implicados-en-la-patogenicidad-de-klebsiella-pneumoniae\/"},"modified":"2018-03-09T09:04:00","modified_gmt":"2018-03-09T09:04:00","slug":"mecanismos-implicados-en-la-patogenicidad-de-klebsiella-pneumoniae","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/mecanismos-implicados-en-la-patogenicidad-de-klebsiella-pneumoniae\/","title":{"rendered":"Mecanismos implicados en la patogenicidad de klebsiella pneumoniae"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Dolores \u00e1lvarez D\u00edaz <\/strong><\/h2>\n<p>Las cepas de k.Pneumoniae suero-sensibles y suero-resistentes, excepto aquellas cepas con serotipos capsulares particulares, activan el sistema del complemento. Las cepas suero-sensibles activan las dos v\u00edas del sistema del complemento mientras que las cepas suero-resistentes activan el sistema del complemento principalmente a trav\u00e9s de la va. Las cepas suero-resistentes reducen la activaci\u00f3n de la vc gracias a la presencia de la cadena o del lps, que inhiben la uni\u00f3n del c1q a las porinas. Se han identificado los componentes de la membrana externa implicados en la uni\u00f3n del c3b, por an\u00e1lisis de western blotting. El lps rugoso es capaz de activar el sistema del complemento, al igual que el lps liso. En k.Pneumoniae la regi\u00f3n del l\u00edpido a de la mol\u00e9cula de lps activa la vc sin la participaci\u00f3n de anticuerpos espec\u00edficos y la cadena o del lps activa la va por un mecan\u00edsmo independiente del l\u00edpido a e independiente de anticuerpo y es el sitio preferente de deposici\u00f3n del c3b en la membrana externa de las cepas de k.Pneumoniae suero-resistentes. Las porinas son el sitio m\u00e1s importante de deposici\u00f3n del c3b y de sus fragmentos de degradaci\u00f3n en las membranas externas de las cepas suero-sensibles de k.Pneumoniae. En experimentos de elisa con componentes bacterianos purificados de k.Pneumoniae, el c3b se une preferentemente a las pornias, al lps liso y al lps rugoso, por este orden. Las cepas suero-sensibles unen mayores cantidades de c3b y de sus fragmentos de degradaci\u00f3n que las cepas suero-resistentes. El patr\u00f3n de degradaci\u00f3n del c3b es similar en los dos tipos de cepas, con ic3b como la forma predominate del c3 depositado.  en los asilamientos cl\u00ednicos de k.Pneumoniae o-, el polisac\u00e1rido capsular proteg\u00e9 al microoorganismo de la muerte por el complemento y de la muerte por opsonofagocitosis, independientemente del serotipo capsular. Al menos en cuantro serotipos capsualres estudiados, la expresi\u00f3n capsular fue requerid<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mecanismos implicados en la patogenicidad de klebsiella pneumoniae<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mecanismos implicados en la patogenicidad de klebsiella pneumoniae <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Dolores \u00e1lvarez D\u00edaz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Illes balears<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Javier Benedi Benito<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jorge Laluca jo <\/li>\n<li>Fernando Vivancos (vocal)<\/li>\n<li>Luis Mart\u00ednez mart\u00ednez (vocal)<\/li>\n<li>m. Torrs Juan (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Dolores \u00e1lvarez D\u00edaz Las cepas de k.Pneumoniae suero-sensibles y suero-resistentes, excepto aquellas cepas con serotipos capsulares particulares, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2193,1418,36483,36606,35,19034,278],"tags":[51905,51907,19953,51906,51908,51909],"class_list":["post-16420","post","type-post","status-publish","format-standard","hentry","category-antibioticos","category-bacteriologia","category-biologia-molecular","category-biologia-molecular-de-microorganismos","category-ciencias-de-la-vida","category-illes-balears","category-microbiologia","tag-dolores-alvarez-diaz","tag-fernando-vivancos","tag-javier-benedi-benito","tag-jorge-laluca-jo","tag-luis-Martinez-Martinez","tag-m-torrs-juan"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16420"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16420\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16420"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16420"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}