{"id":16429,"date":"2018-03-09T09:04:01","date_gmt":"2018-03-09T09:04:01","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-los-reflejos-espinales-nociceptivos-por-aminas-biogenas-estudios-electrofisiologicos-in-vitro\/"},"modified":"2018-03-09T09:04:01","modified_gmt":"2018-03-09T09:04:01","slug":"modulacion-de-los-reflejos-espinales-nociceptivos-por-aminas-biogenas-estudios-electrofisiologicos-in-vitro","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/modulacion-de-los-reflejos-espinales-nociceptivos-por-aminas-biogenas-estudios-electrofisiologicos-in-vitro\/","title":{"rendered":"Modulaci\u00f3n de los reflejos espinales nociceptivos por aminas bi\u00f3genas. estudios electrofisiol\u00f3gicos in vitro"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gonzalo Hedo Aparicio <\/strong><\/h2>\n<p>La transmisi\u00f3n de informaci\u00f3n nociceptiva en la m\u00e9dula espinal es modulada por los sistemas antinociceptivos descendentes que se originan en algunos n\u00facleos del tronco encef\u00e1lico. Estos sistemas emplean diversos neurotransmisores o neuromoduladores entre los que se encuentran serotonina (5-ht) y noradrenalina (na). La liberaci\u00f3n de estos agentes en la m\u00e9dula espinal modula el transito de las se\u00f1ales nociceptivas. En condiciones de inflamaci\u00f3n perif\u00e9rica la m\u00e9dula espinal se sensibiliza, aumentando el flujo de informaci\u00f3n nociceptiva, mientras que los sistemas descendentes aumentan su actividad.  los objetivos de esta tesis doctoral consist\u00eda en:  1,- estudiar los efectos de 5-ht y na sobre los reflejos espinales nociceptivos y caracterizar los receptores que los median.  2,- desarrollar un modelo de sensibilizaci\u00f3n espinal in vitro.  3,- probar en este modelo si la funci\u00f3n o la actividad de los sistemas seroton\u00e9rgico y noradren\u00e9rgico se encuentran alterada.  para llevar a cabo estos estudios se utilizaron fundamentalmente t\u00e9cnicas electrofisiol\u00f3gicas y farmacol\u00f3gicas en un modelo de m\u00e9dula espinal hemiseccionada in vitro de rata joven (6-12 d\u00edas).  serotonina tuvo efectos excitadores e inhibidores sobre los reflejos espinales nociceptivos, lo mismo que noradrenalina. Ambos efectos fueron mimetizados o bloqueados por agonistas y antagonistas espec\u00edficos.  tras una inflamaci\u00f3n de la pata, por inyecci\u00f3n intraplantar de carregenina, los animales desarrollaron hiperalgesia t\u00e9rmica y mec\u00e1nica. Ambas sensibilidades aparec\u00edan poco tiempo tras la lesi\u00f3n. Mientras, los resultados obtenidos en las m\u00e9dulas de estos animales con inflamaci\u00f3n indican que sus reflejos nociceptivos van aumentando a lo largo del periodo de estudio, hasta alcanzar un m\u00e1ximo a 20 horas tras la inyecci\u00f3n (\u00faltimo punto de estudio). Estas m\u00e9dulas tambi\u00e9n ten\u00edan los reflejos no-nociceptivos aumentados presentando caracter\u00edsticas de res<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de los reflejos espinales nociceptivos por aminas bi\u00f3genas. estudios electrofisiol\u00f3gicos in vitro<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de los reflejos espinales nociceptivos por aminas bi\u00f3genas. estudios electrofisiol\u00f3gicos in vitro <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gonzalo Hedo Aparicio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Alcal\u00e1<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> L\u00f3pez Garc\u00eda Jos\u00e9 Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: roberto Gallego fernandez <\/li>\n<li>Manuel Feria rodr\u00edguez (vocal)<\/li>\n<li>\u00e1ngel Pazos carro (vocal)<\/li>\n<li> Rivera de los arcos Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gonzalo Hedo Aparicio La transmisi\u00f3n de informaci\u00f3n nociceptiva en la m\u00e9dula espinal es modulada por los sistemas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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