{"id":16458,"date":"2018-03-09T09:04:03","date_gmt":"2018-03-09T09:04:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-de-los-analgesicos-sobre-la-concentracion-alveolar-minima-cam-de-isofluorano-en-la-rata\/"},"modified":"2018-03-09T09:04:03","modified_gmt":"2018-03-09T09:04:03","slug":"efectos-de-los-analgesicos-sobre-la-concentracion-alveolar-minima-cam-de-isofluorano-en-la-rata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-de-los-analgesicos-sobre-la-concentracion-alveolar-minima-cam-de-isofluorano-en-la-rata\/","title":{"rendered":"Efectos de los analgesicos sobre la concentraci\u00f3n alveolar minima (cam) de isofluorano en la rata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Criado Gonz\u00e1lez <\/strong><\/h2>\n<p>En cualquier procedimiento quir\u00fargico llevado a cabo en animales de laboratorio siempre deber\u00eda confirmarse la existencia de una adecuada analgesia, puesto que constituye un factor clave del refinamiento de la t\u00e9cnica quir\u00fargico-anest\u00e9sica. la amplia difusi\u00f3n de las t\u00e9cnicas de anestesia inhalatoria en roedores hace necesario el estudio de la adecuaci\u00f3n de la analgesia y la interacci\u00f3n existente entre los analg\u00e9sicos y los anest\u00e9sicos. La medida est\u00e1ndar de potencia analg\u00e9sica de los anest\u00e9sicos inhalatorios es la concentraci\u00f3n alveolar m\u00ednima (cam) de dichos agentes, que suprime la respuesta frente a un estimulo doloroso en el 50% de los pacientes. La cam tambi\u00e9n puede utilizarse para medir indirectamente la potencia analg\u00e9sica de otros f\u00e1rmacos, mediante la determinaci\u00f3n de su efecto ahorrador sobre las necesidades de anest\u00e9sicos inhalatorios, es decir el efecto reductor sobre la cam.  en nuestro trabajo determinamos los efectos de cuatro opioides sobre las necesidades de isoflurano en la rata. Para cada uno de los opioides se utilizaron tres dosis, seleccionadas dentro del rango de dosis cl\u00ednicas publicadas para la rata. Se administraron buprenorfina (10, 30 \u00f3 100g\/kg) o morfina (1,3 \u00f3 10 mg\/kg) v\u00eda iv como un bolus, y el fentanilo (15,30 \u00f3 60 g\/kg\/h) y el remifentanilo (60,120 \u00f3 240 g\/kg\/h) se administraron v\u00eda iv como infusi\u00f3n continua. Las dosis utilizadas se seleccionaron dentrol del rango de dosis cl\u00ednicas utilizadas en la rata. Los porcentajes de reducci\u00f3n de la cam de isoflurano obtenidos para cada grupo se pueden ver en la tabla siguiente.  dosis                 buprenorfina    morfina     fentanilo     remifentanilo  baja    medina        13,8            16,9        10,2          10,6  95% cl        (7,8-19,9)      (10,8-23,0) (4,1-16,3)    (4,5-16,6)  media   media         27,5            28,8        26,1          24,1  95% cl        (21,4-33,5)     (22,7-34,8) (20,2-32,1)   (18,0-30,2)  a<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos de los analgesicos sobre la concentraci\u00f3n alveolar minima (cam) de isofluorano en la rata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos de los analgesicos sobre la concentraci\u00f3n alveolar minima (cam) de isofluorano en la rata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Criado Gonz\u00e1lez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Alvarez Gomez Segura Ignacio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: fidel San rom\u00e1n ascaso <\/li>\n<li>Juan  Fernando Herrero  gonzalez (vocal)<\/li>\n<li>Mar\u00eda sol Carrasco jim\u00e9nez (vocal)<\/li>\n<li>Francisco Reinoso barbero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Criado Gonz\u00e1lez En cualquier procedimiento quir\u00fargico llevado a cabo en animales de laboratorio siempre deber\u00eda confirmarse [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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