{"id":16475,"date":"2018-03-09T09:04:06","date_gmt":"2018-03-09T09:04:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudi-de-les-alteracions-dels-mecanismes-reguladors-del-cicle-cel-lular-apoptosi-i-invasio-en-el-carcinoma-de-pra%c2%b2stata\/"},"modified":"2018-03-09T09:04:06","modified_gmt":"2018-03-09T09:04:06","slug":"estudi-de-les-alteracions-dels-mecanismes-reguladors-del-cicle-cel-lular-apoptosi-i-invasio-en-el-carcinoma-de-pra%c2%b2stata","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudi-de-les-alteracions-dels-mecanismes-reguladors-del-cicle-cel-lular-apoptosi-i-invasio-en-el-carcinoma-de-pra%c2%b2stata\/","title":{"rendered":"Estudi de les alteracions dels mecanismes reguladors del cicle cel.lular, apoptosi i invasi\u00f3 en el carcinoma de pr\u00f3stata"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier Farr\u00e9 Pueyo <\/strong><\/h2>\n<p>En esta tesis se ha hipotetizado sobre la existencia de alteraciones en la expresi\u00f3n de genes reguladores del ciclo celular, de la apoptosis y en los agentes que intervienen en la adquisici\u00f3n del fenotipo metast\u00e1sico a diferentes niveles, desde una fase inicial premaligna hasta las fases m\u00e1s avanzadas metast\u00e1sicas en carcinomas prost\u00e1ticos de enfermos en nuestro medio.  se han establecido las siguientes conclusiones:  1,- la sobreexpresi\u00f3n de p53 en el modelo de neoplasia prost\u00e1tica se ha encontrado predominantemente en la fase de carcinoma de pr\u00f3stata, lo cual apoya la hip\u00f3tesis que la expresi\u00f3n de p53 mutada sucede en etapes tard\u00edas de la crcinog\u00e9nesis de la gl\u00e1ndula prost\u00e1tica. La asociaci\u00f3n de la sobreexpresi\u00f3n de p53 con ciertos par\u00e1metros cl\u00ednico-patol\u00f3gicos, como el margen de resecci\u00f3n positivo y la fase s, probablemente se debe a su asociaci\u00f3n con el grado histol\u00f3gico.  2,- la frecuente sobreexpresi\u00f3n del bcl-2 observada en la neoplasia prost\u00e1tica intraepitelial de alto grado sugiere un papel de este gen antiapopt\u00f3tico en la tumorog\u00e9nesis prost\u00e1tica inicial, donde podr\u00eda actuar como factor de supervivencia para contrarrestar un posible aumento de la apoptosis en lesiones premalignas y permitiendo la progresi\u00f3n tumoral.  3,- la sobreexpresi\u00f3n aberrante de p21 wafl\/cip1 en las c\u00e9lulas tumorales caracteriza a un subgrupo de pacientes con un curso cl\u00ednico desfavorable, lo cual podr\u00eda ser debido a su asociaci\u00f3n con el grado histol\u00f3gico. La regulaci\u00f3n del punto de restricci\u00f3n fisiol\u00f3gica g1\/s del ciclo celular pdor\u00eda estar alterado, con participaci\u00f3n de mecanismos de activaci\u00f3n de p21 walf\/cip1 independientes de p53. Por otra parte, la falta de expresi\u00f3n de p21 walf\/cip1 no parece tener un papel relevante, al no encontrarse asociada a otros par\u00e1metros cl\u00ednico-patol\u00f3gicos.  4,- p27kip1 se encuentra expresado intensamente en el epitelio prost\u00e1tico normal e hiperpl\u00e1sico y la regulaci\u00f3n<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudi de les alteracions dels mecanismes reguladors del cicle cel.lular, apoptosi i invasi\u00f3 en el carcinoma de pr\u00f3stata<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudi de les alteracions dels mecanismes reguladors del cicle cel.lular, apoptosi i invasi\u00f3 en el carcinoma de pr\u00f3stata <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier Farr\u00e9 Pueyo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 19\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Cardesa Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pablo Carretero gonz\u00e1lez <\/li>\n<li> C\u00f3zar olmo Jos\u00e9 Manuel (vocal)<\/li>\n<li>Antonio Palacin forgue (vocal)<\/li>\n<li>teresa Ribalta farres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier Farr\u00e9 Pueyo En esta tesis se ha hipotetizado sobre la existencia de alteraciones en la expresi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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