{"id":1653,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/preparacion-y-estudio-de-nuevos-inhibidores-de-catecol-o-metiltransferasa-de-interes-terapeutico-potencial\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"preparacion-y-estudio-de-nuevos-inhibidores-de-catecol-o-metiltransferasa-de-interes-terapeutico-potencial","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/preparacion-y-estudio-de-nuevos-inhibidores-de-catecol-o-metiltransferasa-de-interes-terapeutico-potencial\/","title":{"rendered":"Preparacion y estudio de nuevos inhibidores de catecol-o-metiltransferasa de interes terapeutico potencial."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Perez Martin Rosa Ana <\/strong><\/h2>\n<p>El objetivo del trabajo recogido en la memoria de tesis es la obtencion de inhibidores de comt, capaces de interaccionar selectivamente con el enzima y ofrezcan la posibilidad de emplearse con fines terapeuticos. La sintesis y estudio de nitroderivados de hidroximetoxi y dihidroxibanzaldehido, permitio establecer que en los dihidroxiderivados la presencia de un grupo nitro en orto respecto a uno de los grupos hidroxilos incrementa su actividad como inhibidores de este enzima.  se sintetizaron y ensayaron como inhibidores de comt una serie de 1- vinilderivados de nitrocatecol y nitroguaiacol; actuando todos ellos como buenos inhibidores del enzima. Unicamente uno de los compuestos ensayados actuaba como inhibidor irreversible, modificando dos grupos sh del enzima con diferente reactividad. El estudio de uno de los productos que actuaban como inhibidores reversibles, mostro que se trataba de un inhibidor \u00abtight-binding\u00bb. Tambien se sintetizo y ensayo un producto con cadena en 1 de mayor longitud entre el anillo y el-doble enlace.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Preparacion y estudio de nuevos inhibidores de catecol-o-metiltransferasa de interes terapeutico potencial.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Preparacion y estudio de nuevos inhibidores de catecol-o-metiltransferasa de interes terapeutico potencial. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Perez Martin Rosa Ana <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ofelia Nieto Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Soto Camar Jos\u00e9 Luis <\/li>\n<li>Enrique Palacian Gil (vocal)<\/li>\n<li>Antonio Monge Vega (vocal)<\/li>\n<li>Antonio Sillero Repullo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Perez Martin Rosa Ana El objetivo del trabajo recogido en la memoria de tesis es la obtencion [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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