{"id":16571,"date":"2018-03-09T09:04:15","date_gmt":"2018-03-09T09:04:15","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/inflamacion-y-secrecion-glandular-en-la-mucosa-respiratoria-regulacion-por-glucocorticoides\/"},"modified":"2018-03-09T09:04:15","modified_gmt":"2018-03-09T09:04:15","slug":"inflamacion-y-secrecion-glandular-en-la-mucosa-respiratoria-regulacion-por-glucocorticoides","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/inflamacion-y-secrecion-glandular-en-la-mucosa-respiratoria-regulacion-por-glucocorticoides\/","title":{"rendered":"Inflamaci\u00f3n y secreci\u00f3n glandular en la mucosa respiratoria. regulaci\u00f3n por glucocorticoides"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jordi Roca Ferrer <\/strong><\/h2>\n<p>Las c\u00e9lulas epiteliales obtenidas de mucosa nasal expresan arnm de il-8 y gm-csf. Una vez en cultivo, sintetizan y secretan il-1beta, il-6, il-8, tnf-alfa y gm-csf. La dexanetasona a 10 um inhibe la secreci\u00f3n de gm-csf, il-6, il-8 y tnf-alfa por las c\u00e9lulas epiteliales. La supervivencia de los eosin\u00f3gilos es estimulada por el sobrenadante de los cultivos de c\u00e9lulas epiteliales nasales, siendo bloqueada por la adici\u00f3n de anticuerpos contra gm-csf, tnf-alfa y il-8. Los corticoides, incubados con las c\u00e9lulas epiteliales, inhiben el efecto estimulante de la supervivencia de los eosin\u00f3filos que tienen las secreciones epiteliales, inhiben el efecto estimulante de la supervivencia de los eosin\u00f3filos que tienen las secreciones epiteliales. adem\u00e1s, la incubaci\u00f3n de los eosin\u00f3filos con corticoides inhiben de forma dosis dependiente la supervivencia inducida por secreciones epiteliales. la secreci\u00f3n glandular de lactoferrina en mucosa nasal es estimulada por metacolina, ecp y las citocinas tnf-alfa, il-1beta y gm-csf. La secreci\u00f3n glandular en la mucosa bronquial tambi\u00e9n es estimulada por metacolina. los corticoides budesonida y beclometasona disminuye la secrecci\u00f3n glandular espontanea de lactoferrina tanto en mucosa nasal como bronquial. La budesonida tiene un efecto inhibidor dosis dependiente sobre la secreci\u00f3n de lactoferrina inducida por metacolina en la mucosa bronquial y nasal, inhibiendo tambi\u00e9n en forma dosis dependiente la secreci\u00f3n estimulada por las citocinas il-1beta y tnf-alfa en mucosa nasal.  por lo tanto, las c\u00e9lulas epiteliales parecen tener un papel importante en la inducci\u00f3n y mantenimiento de la inflamaci\u00f3n en la mucosa respiratoria, modulando tanto la presencia de eosin\u00f3filos como la secreci\u00f3n glandular. la eficacia de los corticoides en el tratamiento de las enfermedades inflamatorias de la mucosa respiratoria se debe a un efecto m\u00faltiple, actuando tanto sobre las c\u00e9lulas epiteliales, como sobre los e<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Inflamaci\u00f3n y secreci\u00f3n glandular en la mucosa respiratoria. regulaci\u00f3n por glucocorticoides<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Inflamaci\u00f3n y secreci\u00f3n glandular en la mucosa respiratoria. regulaci\u00f3n por glucocorticoides <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jordi Roca Ferrer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 25\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>C\u00e9sar Picado Vall\u00e9s<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: joaquin Sanchis aldas <\/li>\n<li> De bol\u00f3s pi carme (vocal)<\/li>\n<li>conxita De castellarnau castell\u00ed\u00a0 (vocal)<\/li>\n<li>emili Gelpi monteys (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jordi Roca Ferrer Las c\u00e9lulas epiteliales obtenidas de mucosa nasal expresan arnm de il-8 y gm-csf. Una [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,849,35,9399,1989],"tags":[13826,14102,52286,52287,11556,52285],"class_list":["post-16571","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-celular","category-ciencias-de-la-vida","category-cultivo-celular","category-cultivo-de-tejidos","tag-cesar-picado-valles","tag-conxita-de-castellarnau-castelli","tag-de-bolos-pi-carme","tag-emili-gelpi-monteys","tag-joaquin-sanchis-aldas","tag-jordi-roca-ferrer"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16571","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16571"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16571\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16571"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16571"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16571"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}