{"id":16628,"date":"2018-03-09T09:04:20","date_gmt":"2018-03-09T09:04:20","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citotoxicidad-de-las-proteasas-2a-y-3c-del-virus-de-la-polio\/"},"modified":"2018-03-09T09:04:20","modified_gmt":"2018-03-09T09:04:20","slug":"citotoxicidad-de-las-proteasas-2a-y-3c-del-virus-de-la-polio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/citotoxicidad-de-las-proteasas-2a-y-3c-del-virus-de-la-polio\/","title":{"rendered":"Citotoxicidad de las proteasas 2a y 3c del virus de la polio"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Calandria P\u00e9rez Carlos Mario <\/strong><\/h2>\n<p>Para profundizar en el estudio de la citoxicidad producida por la expresi\u00f3n de las proteasas 2a y 3c del virus de la polio, hemos analizado la muerte celular provocada por la expresi\u00f3n de estas proteasas. Para ello, hemos utilizado clones de c\u00e9lulas hela que expresan de forma inducible y dependiente de tetraciclina las proteasas virales mediante el sistema tet-off.  mediante el an\u00e1lisis de algunas alteraciones morfol\u00f3gicas y bioqu\u00edmicas que se producen en las c\u00e9lulas despu\u00e9s de la expresi\u00f3n de las proteasa virales, pudimos concluir que la expresi\u00f3n inducible de estas proteasas de virus de la polio inducen una respuesta apopt\u00f3tica en c\u00e9lulas hela dpendiente de caspasas. La diferencia m\u00e1s importante que encontramos fue la cin\u00e9tica de aparici\u00f3n de los distintos cambios caracter\u00edsticos de apoptosis: en las c\u00e9lulas que expresan 3c estos cambios se apreciaban m\u00e1s tarde.  adem\u00e1s hemos estudiado el efecto de la expresi\u00f3n de estas proteasas sobre la s\u00edntesis de macromol\u00e9culas. En particular el efecto de la proteasa 2a sobre la s\u00edntesis de prote\u00ednas y el de la 3c sobre la transcripci\u00f3n celular. En este caso se reforz\u00f3 la opini\u00f3n existente que implica a la proteasa 2a en la inhibici\u00f3n de la traducci\u00f3n dependiente de cap, y a la 3c en la inhibici\u00f3n de la transcripci\u00f3n celular, ambos efectos encontrados en la infecci\u00f3n con el virus de la polio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Citotoxicidad de las proteasas 2a y 3c del virus de la polio<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Citotoxicidad de las proteasas 2a y 3c del virus de la polio <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Calandria P\u00e9rez Carlos Mario <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Luis Carrasco Llamas<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Fernandez piqueras <\/li>\n<li> Nieva escand\u00f3n Jos\u00e9 Luis (vocal)<\/li>\n<li> Gonz\u00e1lez portal m. eugenia (vocal)<\/li>\n<li>Francisco Javier Benavente mart\u00ednez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Calandria P\u00e9rez Carlos Mario Para profundizar en el estudio de la citoxicidad producida por la expresi\u00f3n de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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