{"id":16666,"date":"2018-03-09T09:04:23","date_gmt":"2018-03-09T09:04:23","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/identificacion-de-los-epitopos-continuos-fijadores-de-ige-de-la-tropomiosina-pen-a-1-el-alergeno-mayor-de-la-gamba-penaeus-aztecus\/"},"modified":"2018-03-09T09:04:23","modified_gmt":"2018-03-09T09:04:23","slug":"identificacion-de-los-epitopos-continuos-fijadores-de-ige-de-la-tropomiosina-pen-a-1-el-alergeno-mayor-de-la-gamba-penaeus-aztecus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/identificacion-de-los-epitopos-continuos-fijadores-de-ige-de-la-tropomiosina-pen-a-1-el-alergeno-mayor-de-la-gamba-penaeus-aztecus\/","title":{"rendered":"Identificaci\u00f3n de los epitopos continuos fijadores de ige de la tropomiosina (pen a 1), el alergeno mayor de la gamba penaeus aztecus"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rosalia Ayuso Caballero <\/strong><\/h2>\n<p>Las reacciones de hipersensibilidad a marisco y en especial a crust\u00e1ceos, son de las m\u00e1s frecuentes y persistentes de las reacciones al\u00e9rgicas a alimentos. Sin embargo, a pesar de la severidad de las reacciones, el \u00fanico tratamiento disponible actualmente consiste en la evitaci\u00f3n del alimento, lo cual no siempre es posible. Previos estudios han identificado la tropomiosina como el al\u00e9rgeno mayor de la gamba penaeus aztecus. Otras tropomiosinas de invertebrados son alerg\u00e9nicas, mientras que las de vertebrados no lo son, haciendo de la tropomiosina un modelo especialmente adecuado para el estudio de la alergenicidad de las prote\u00ednas. Este estudio se plante\u00f3 identificar los ep\u00edtopos fijadores de ige de pen a 1, con prop\u00f3sito primero de identificar las caracter\u00edsticas estructurales responsables de la alergenicidad. en segundo lugar, sentar las bases para la producci\u00f3n de variantes de pen a 1 con m\u00ednimo capacidad fijadora de ige, y p\u00e9ptidos recombinantes modificados para el tratamiento de pacientes al\u00e9rgicos a curst\u00e1ceos, y en tercer lugar, para identificar los ep\u00edtopos responsables de la reactividad cruzada entre invertebrados, utilizando para el estudio la t\u00e9cnica de p\u00e9ptidos sint\u00e9ticos solapantes de genosys.  cinco regiones mayores fijadores de ige fueron identificadas, que contienen al menos 8 ep\u00edtopos mayores. El reconocimiento de p\u00e9ptidos lineales, apoya la importancia de los p\u00e9ptidos lineales en la alergia alimentos. Las 5 regiones mayores contienen la secuencia de amino\u00e1cidos lexxl, la cual podr\u00eda ser utilizada como posible marcador de alergenicidad en la evaluaci\u00f3n aleg\u00e9nica de las prote\u00ednas. En cada ep\u00edtopo se han identificado una o m\u00e1s substituciones de amino\u00e1cidos que disminuyen o abolen la fijaci\u00f3n de ige a ese p\u00e9ptido, que podr\u00eda ser utilizado en el futuro para inmunoterapia con menor riesgo de reacciones al\u00e9rgicas. Por \u00faltimo, la homolog\u00eda de los ep\u00edtopos de pen a 1 con otras tropomiosinas d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Identificaci\u00f3n de los epitopos continuos fijadores de ige de la tropomiosina (pen a 1), el alergeno mayor de la gamba penaeus aztecus<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Identificaci\u00f3n de los epitopos continuos fijadores de ige de la tropomiosina (pen a 1), el alergeno mayor de la gamba penaeus aztecus <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rosalia Ayuso Caballero <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 29\/04\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Gerald Preese<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Merrera pombo Jos\u00e9 Luis <\/li>\n<li>f\u00e9lix Lorente toledano (vocal)<\/li>\n<li> Pereda Garc\u00eda Juan  Manuel (vocal)<\/li>\n<li> Zubeldia ortu\u00f1o Jos\u00e9 Manuel (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rosalia Ayuso Caballero Las reacciones de hipersensibilidad a marisco y en especial a crust\u00e1ceos, son de las 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