{"id":16694,"date":"2002-02-05T00:00:00","date_gmt":"2002-02-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estres-oxidativo-y-niveles-de-8-oxo-2a-deoxiguanosina-en-la-leucemia-linfoca%c2%adtica-cronica\/"},"modified":"2002-02-05T00:00:00","modified_gmt":"2002-02-05T00:00:00","slug":"estres-oxidativo-y-niveles-de-8-oxo-2a-deoxiguanosina-en-la-leucemia-linfoca%c2%adtica-cronica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estres-oxidativo-y-niveles-de-8-oxo-2a-deoxiguanosina-en-la-leucemia-linfoca%c2%adtica-cronica\/","title":{"rendered":"Estr\u00e9s oxidativo y niveles de 8-oxo-2\u00c2\u00bf deoxiguanosina en la leucemia linfoc\u00edtica cr\u00f3nica."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Oltra Benavent Ana M. <\/strong><\/h2>\n<p>El estr\u00e9s oxidativo se ha relacionado con la transformaci\u00f3n maligna celular, interviniendo en la carcinog\u00e9nesis. La formaci\u00f3n incrementada de radiales libres oxig\u00e9nicos, y la alteraci\u00f3n de los antioxidantes enzim\u00e1ticos, son responsables de las lesiones a nivel del adn,y otras mol\u00e9culas (prote\u00ednas y l\u00edpidos), que determinan un estado de oxidaci\u00f3n celular y una mayor susceptibilidad a las mutaciones. La etiopatogenia de la leucemia linfoc\u00edtica cr\u00f3nica (llc) es hoy objeto de estudio. Es un proceso linfoproliferativo, con alteraciones en la regulaci\u00f3n de la apoptosis y en la deleci\u00f3n de c\u00e9lulas b disreguladas, en las que el estr\u00e9s oxidativo puede estar implicado.  nosotros hemos estudiado las actividades de las enzimas super\u00f3xido dismutasa (sod), catalasa (cat) y glutati\u00f3n peroxidasa (gpx), y la relaci\u00f3n glutati\u00f3n oxidado y reducido (gssg\/gsh%), junto con productos resultado de la oxidaci\u00f3n celular, como malondealdeh\u00eddo (mda) y a nivel del adn, la 8-oxo-2\u00c2\u00bfdesoxiguanosina (8-oxo-dg), en poblaci\u00f3n de c\u00e9lulas mononucleares, de pacientes afectos de llc,que no hab\u00edan recibido tratamiento al inicio de nuestro estudio, comparando con una poblaci\u00f3n control. Las actividades de sod y cat descienden en poblaci\u00f3n mononuclear, con respecto a los controles, mientras que la actividad de gpx se incrementa. El contenido de gsh tambi\u00e9n se incrementa en la llc, mientras que apenas se modifica el gssg; as\u00ed la relaci\u00f3n gssg\/gsh tambi\u00e9n se incrementa en la llc, mientras que apenas se modifica el gssg; as\u00ed la relaci\u00f3n gsg\/gsh desciende en estos pacientes. El producto de la peroxidaci\u00f3n lip\u00eddica mda y la 8-oxo-dg, tambi\u00e9n se incrementan en la llc. la evoluci\u00f3n temporal de la enfermedad, se acompa\u00f1a a su vez, de una progresiva alteraci\u00f3n de los par\u00e1metros del metabolismo oxidativo estudiados. Tambi\u00e9n se observan correlaciones significativas entre los par\u00e1metros, gpx, cat, sod, glutati\u00f3n y mda, y los utilizados en el estudio<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estr\u00e9s oxidativo y niveles de 8-oxo-2\u00c2\u00bf deoxiguanosina en la leucemia linfoc\u00edtica cr\u00f3nica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estr\u00e9s oxidativo y niveles de 8-oxo-2\u00c2\u00bf deoxiguanosina en la leucemia linfoc\u00edtica cr\u00f3nica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Oltra Benavent Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Felix Carbonell Ramon<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Cabo soler jos ricardo <\/li>\n<li>pedro Puig pavellada (vocal)<\/li>\n<li>Antonio Iradi nasal (vocal)<\/li>\n<li>agustin Rios gonzalez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Oltra Benavent Ana M. El estr\u00e9s oxidativo se ha relacionado con la transformaci\u00f3n maligna celular, interviniendo en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,189,347],"tags":[9428,52621,52619,39952,52618,52620],"class_list":["post-16694","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-farmacodinamia","category-oncologia-clinica","tag-agustin-rios-gonzalez","tag-antonio-iradi-nasal","tag-cabo-soler-jos-ricardo","tag-felix-carbonell-ramon","tag-oltra-benavent-ana-m","tag-pedro-puig-pavellada"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16694","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16694"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16694\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16694"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16694"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16694"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}