{"id":16695,"date":"2002-02-05T00:00:00","date_gmt":"2002-02-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/el-etamsilato-como-farmaco-hemostatico-en-la-cla%c2%adnica-del-bovino\/"},"modified":"2002-02-05T00:00:00","modified_gmt":"2002-02-05T00:00:00","slug":"el-etamsilato-como-farmaco-hemostatico-en-la-cla%c2%adnica-del-bovino","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/el-etamsilato-como-farmaco-hemostatico-en-la-cla%c2%adnica-del-bovino\/","title":{"rendered":"El etamsilato como f\u00e1rmaco hemost\u00e1tico en la cl\u00ednica del bovino"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josep Manel Homedes Beguer <\/strong><\/h2>\n<p>El etamsilato es utilizado en b\u00f3vidos para el control de la hemostasia a pesar de no existir publicaciones cient\u00edficas que demuestren su seguridad y eficacia en esta especie. Sin embargo, existen diversos trabajos que han demostrado sus efectos hemost\u00e1ticos en otras especies animales. Para documentar experimentalmente su utilizaci\u00f3n en vacuno, se han llevado a cabo tres estudios: un estudio farmacocin\u00e9tico tras la administraci\u00f3n intravenosa (iv) e intramuscular (im) de una dosis de 7,5 mg\/kg. Un estudio de tolerancia local, tras la administraci\u00f3n \u00fanica de 7,5 mg\/kg por v\u00eda im, y de tolerancia general tras administrar 25 mg\/kg\/24h (iv) durante 10 d\u00edas. Y un tercer estudio de eficacia evaluando su capacidad en reducir el tiempo de sangr\u00eda (ts) administrando una dosis \u00fanica de 12,5 mg\/kg (iv).  las concentraciones plasm\u00e1ticas tras la administraci\u00f3n iv mostraron un volumen de distribuci\u00f3n (vd) de 0,44+-0,10 l\/kg, un aclaramiento (c1) de 0,21+-0,04 l\/h.Kg y una semivida de eliminaci\u00f3n (t1\/2) de 1,49+-0,16 h. tras su administraci\u00f3n im se observ\u00f3 una biodisponibilidad (f) superior al 98%. El estudio de tolerancia revel\u00f3 una ausencia de efectos tanto a nivel local, medida por las variaciones en la enzima creatin-kinasa, como general, valorada por la sintomatolog\u00eda cl\u00ednica y diversos par\u00e1metros sangu\u00edneos (hematol\u00f3gicos, bioqu\u00edmicos y hemost\u00e1ticos). El estudio de eficacia mostr\u00f3 un descenso significativo del ts del 16% respecto a sus valores basales dos horas despu\u00e9s  de la administraci\u00f3n iv. El porcentaje de disminuci\u00f3n del ts fue mayor en aquellos animales con el ts basal m\u00e1s largo, mostrando una correlaci\u00f3n estad\u00edsticamente significativa. El porcentaje medio de reducci\u00f3n fue menor a los descritos para otras especies y no alcanz\u00f3 diferencias estad\u00edsticamente significativas respecto al control.  se concluye que el etamsilato es un f\u00e1rmaco \u00fatil para su uso en vacuno, siendo muy seguro y mostrando una eficacia<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>El etamsilato como f\u00e1rmaco hemost\u00e1tico en la cl\u00ednica del bovino<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 El etamsilato como f\u00e1rmaco hemost\u00e1tico en la cl\u00ednica del bovino <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josep Manel Homedes Beguer <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Llu\u00eds Monreal Bosch<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: llu\u00eds Vi\u00f1as borrell <\/li>\n<li>escolastico Aguilera tejero (vocal)<\/li>\n<li>margarita Arboix arbo (vocal)<\/li>\n<li>Luis eusebio Fidalgo \u00e1lvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josep Manel Homedes Beguer El etamsilato es utilizado en b\u00f3vidos para el control de la hemostasia a 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