{"id":16706,"date":"2002-03-05T00:00:00","date_gmt":"2002-03-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-expresion-de-p53-bcl-2-y-bax-en-carcinoma-epidermoide-de-cabeza-y-cuello\/"},"modified":"2002-03-05T00:00:00","modified_gmt":"2002-03-05T00:00:00","slug":"valor-pronostico-de-la-expresion-de-p53-bcl-2-y-bax-en-carcinoma-epidermoide-de-cabeza-y-cuello","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-la-expresion-de-p53-bcl-2-y-bax-en-carcinoma-epidermoide-de-cabeza-y-cuello\/","title":{"rendered":"Valor pron\u00f3stico de la expresi\u00f3n de p53, bcl-2 y bax en carcinoma epidermoide de cabeza y cuello"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Susana Casado Cobo <\/strong><\/h2>\n<p>Los tumores de cabeza y cuello suponen el 5% del total y generalmente se diagnostican en estad\u00edos avanzados, siendo en estos casos el tratamiento standard la cirug\u00eda y\/o radioterapia, seg\u00fan las caracter\u00edsticas del centro y paciente, con una supervivencia a los 5 a\u00f1os inferior al 20%.  en los \u00faltimos a\u00f1os se incorpora la quimioterapia, aportando los tratamientos convinados una alta tasa de respuesta pero con una gran toxicidad. Sin embargo estos tratamientos no aumentan de una forma global la supervivencia, aunque s\u00ed es beneficioso en los pacientes respondedores. Se trata, pues, de identificar factores de respuesta que permitan seleccionar a aquellos pacientes respondedores. Teniendo en cuenta al c\u00e1ncer como una enfermedad gen\u00e9tica, y con el desarrollo emergente en las \u00faltimas d\u00e9cadas de la biolog\u00eda molecular, son numerosos los intentos en detectar las inestabilidades gen\u00e9ticas que se relacionan con el pron\u00f3stico tumoral tanto en su biolog\u00eda natural como en la respuesta de diferentes tratamientos.  sobre esta base analizamos 43 pacientes diagnosticados de carcinoma epidermoide de cavidad oral y orofaringe localmente avanzados, 3 oncoprote\u00ednas implicadas en la apoptosis: p53, pax y bcl2. Los pacientes fueron tratados con quimioterapia (3 ciclos con cispletina y 5 fluoracilo, esquema alsarraf) y radioterapia con intenci\u00f3n neoadyuvante y posterior cirug\u00eda. La respuesta al tratamiento de abducci\u00f3n fue del 83%, presentando los pacientes respondedores una supervivencia 8,9 veces mayor a los 80 meses que los no respondedores. por inmunohistoqu\u00edmica se obtuvo una expresi\u00f3n de p53, bax y bcl2 del 47,5%, 19,5% y 10,8% respectivamente. No tuvimos relaci\u00f3n significativa entre la expresi\u00f3n de las prote\u00ednas con la respuesta al tratamiento ni supervivencia. probablemente las diferentes t\u00e9cnicas de determinaci\u00f3n de las oncoprote\u00ednas, tejidos analizados, peque\u00f1o n\u00famero de muestras inclu\u00eddas &#8230; Hacen que los prometedores resu<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pron\u00f3stico de la expresi\u00f3n de p53, bcl-2 y bax en carcinoma epidermoide de cabeza y cuello<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pron\u00f3stico de la expresi\u00f3n de p53, bcl-2 y bax en carcinoma epidermoide de cabeza y cuello <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Susana Casado Cobo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 03\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rafael L\u00f3pez L\u00f3pez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: javier Garc\u00eda conde <\/li>\n<li>torcuato Labella caballero (vocal)<\/li>\n<li>Luis Miguel Anton aparicio (vocal)<\/li>\n<li>carmen Porto v\u00e1zquez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Susana Casado Cobo Los tumores de cabeza y cuello suponen el 5% del total y generalmente se [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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