{"id":16767,"date":"2002-08-05T00:00:00","date_gmt":"2002-08-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/citoproteccion-miocardica-efecto-de-la-trimetazidina-en-la-isquemia-miocardica\/"},"modified":"2002-08-05T00:00:00","modified_gmt":"2002-08-05T00:00:00","slug":"citoproteccion-miocardica-efecto-de-la-trimetazidina-en-la-isquemia-miocardica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/citoproteccion-miocardica-efecto-de-la-trimetazidina-en-la-isquemia-miocardica\/","title":{"rendered":"Citoprotecci\u00f3n miocardica: efecto de la trimetazidina en la isquemia miocardica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pedro Jose Morillas Blasco <\/strong><\/h2>\n<p>Se analizan las consecuencias funcionales y ultraestructurales del tratamiento con trimetazidina (tmz) en dos modelos caninos de aturdimiento mioc\u00e1rdico: un modelo de isquemias breves (2 minutos) y repetidas (20) seguidas de 3 minutos de reperfusi\u00f3n (protocolo i) y un modelo de isquemia \u00fanica de 15 minutos de duraci\u00f3n y 60 minutos de reperfusi\u00f3n (protocolo 2).  se han utilizado 30 perros mestizos, randomizados a doble ciego, a tratamiento con placebo o a tratamiento con tmz durante una semana (dosis de 50 mg a las 08:00 horas y 75 mg a las 15:00 horas). Las variables analizadas han sido: par\u00e1metros hemodin\u00e1micos (frecuencia card\u00edaca, presi\u00f3n ventricular izquierda y dp\/dt), par\u00e1metros de funci\u00f3n regional de la zona isqu\u00e9mica y de una zona control (di\u00e1metro telesist\u00f3lico y telediat\u00f3lico y fracci\u00f3n de acortamiento) y estudio ultraestructural mediante microscop\u00eda electr\u00f3nica de las mitocondrias (da\u00f1o y tama\u00f1o mitocondriales).  cuando el miocardio es sometido al protocolo 1, se objetiva en la serie placebo una depresi\u00f3n de la funci\u00f3n contr\u00e1ctil segmentaria durante la obstrucci\u00f3n coronaria, que persiste a pesar de la restauraci\u00f3n completa del flujo coronario (64% del valor basal). Paralelamente se observa un aumento significativo en el tama\u00f1o de la mitocondrias, con un ligero incremento en el da\u00f1o mitocondrial y en el porcentaje de vacuolas y gr\u00e1nulos de lipofucsina. En la serie tratada con tmz, se observa una tendencia hacia la mejor\u00eda en el comportamiento de la fracci\u00f3n de acortamiento de la zona isqu\u00e9mica durante las fases de reperfusi\u00f3n, as\u00ed como un menor deterioro de la funci\u00f3n regional al final de la experimentaci\u00f3n (97% del valor basal). En el estudio ultraestructural de la zona isqu\u00e9mica, no se objetivan diferencias en cuanto al da\u00f1o mitocondrial entre ambas series, si bien las mitocondrias tratadas con tmz presentan un aumento significativo en el per\u00edmetro y eje mayor y una disminuci\u00f3n en el eje m<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Citoprotecci\u00f3n miocardica: efecto de la trimetazidina en la isquemia miocardica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Citoprotecci\u00f3n miocardica: efecto de la trimetazidina en la isquemia miocardica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pedro Jose Morillas Blasco <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Universitat de val\u00e9ncia (estudi general)<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 08\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan Cosin Aguilar<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Zarco gutierrez <\/li>\n<li>Francisco Javier Chorro gasc\u00f3 (vocal)<\/li>\n<li> Cruz fernandez Jos\u00e9 m. (vocal)<\/li>\n<li>Francisco Navarro lopez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pedro Jose Morillas Blasco Se analizan las consecuencias funcionales y ultraestructurales del tratamiento con trimetazidina (tmz) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,2189],"tags":[52805,11531,19698,41952,52804,7413],"class_list":["post-16767","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-cirugia-cardiaca","tag-cruz-fernandez-jose-m","tag-francisco-javier-chorro-gasco","tag-francisco-navarro-lopez","tag-juan-cosin-aguilar","tag-pedro-jose-morillas-blasco","tag-pedro-zarco-gutierrez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16767","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16767"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16767\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16767"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16767"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16767"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}