{"id":16797,"date":"2002-10-05T00:00:00","date_gmt":"2002-10-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/factores-pronosticos-biologicos-en-el-cancer-de-laringe\/"},"modified":"2002-10-05T00:00:00","modified_gmt":"2002-10-05T00:00:00","slug":"factores-pronosticos-biologicos-en-el-cancer-de-laringe","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/factores-pronosticos-biologicos-en-el-cancer-de-laringe\/","title":{"rendered":"Factores pronosticos biologicos en el c\u00e1ncer de laringe"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Garcia Lozano M. Cristina <\/strong><\/h2>\n<p>Introducci\u00f3n  el carcinoma epidermoide de laringe es el tumor maligno m\u00e1s frecuente de la regi\u00f3n de la cabeza y el cuello, y aunque presenta elevadas tasas de curaci\u00f3n, la mortalidad de estos enfermos apenas se han modificado en las \u00faltimas d\u00e9cadas. Adem\u00e1s los factores pron\u00f3sticos que manejamos en nuestra pr\u00e1ctica cl\u00ednica diaria no muestran ser los suficientemente precisos para predecir la evoluci\u00f3n de estos enfermos. Por todo ello es necesario hallar nuevos factores pron\u00f3sticos en este tipo de tumores. Entre dichos factores est\u00e1 el estudio de las prote\u00ednas que regulan el ciclo celular, dado que en el c\u00e1ncer se produce un descontrol del mismo.  material y m\u00e9todos  hemos realizado un estudio restrospectivo de 195 pacientes con el diagn\u00f3stico de c\u00e1ncer de laringe que fueron tratados y revisados durante un tiempo m\u00ednimo de 5 a\u00f1os en el servicio de orl del hospital \u00abvirgen de la salud\u00bb de toledo (espa\u00f1a). Se ha llevado a cabo un estudio inmunohistoqu\u00edmico de 10 prote\u00ednas implicadas en la regulaci\u00f3n del ciclo celular (ki-67, p53,  p21 waf1, p27 kip1, rb, mdm2, bcl-2, ciclina a, ciclina d1 y ciclina d3). mediante an\u00e1lisis estad\u00edstico (an\u00e1lisis univariante y multivariante) se ha estudiado el valor pron\u00f3stico de la expresi\u00f3n inmunohistoqu\u00edmica de dichas prote\u00ednas en el c\u00e1ncer de laringe, en comparaci\u00f3n con otros par\u00e1metros clinicopatol\u00f3gicos cl\u00e1sicos. Tambi\u00e9n analizamos el grado de concordancia en la expresi\u00f3n de dichas prote\u00ednas a nivel del tumor primario y a nivel de las met\u00e1stasis ganglionares correspondientes, en los casos en los que hubo afectaci\u00f3n ganglionar.  resultados  el 54,4% de los tumores fueron ki-67 positivos y el 45,6% fueron p53 positivos. El 17,4% de nuestros tumores fueron rb negativos. Mdm2 se expres\u00f3 s\u00f3lo en el 28% de nuestros casos. La expresi\u00f3n de las prote\u00ednas p21 y p27 fue del 69% y del 54% respectivamente. La ciclina d1 apenas se expres\u00f3 en los tumores de nuestra serie<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Factores pronosticos biologicos en el c\u00e1ncer de laringe<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Factores pronosticos biologicos en el c\u00e1ncer de laringe <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Garcia Lozano M. Cristina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joaquin Poch Broto<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julian Sanz <\/li>\n<li>Jos\u00e9 Frassena (vocal)<\/li>\n<li>Antonio Cavedela (vocal)<\/li>\n<li> Caballero (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Garcia Lozano M. Cristina Introducci\u00f3n el carcinoma epidermoide de laringe es el tumor maligno m\u00e1s frecuente de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,35,9,817,347,1226],"tags":[52887,52888,52884,6732,52886,52885],"class_list":["post-16797","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-humana","category-oncologia-clinica","category-otorrinolaringologia","tag-antonio-cavedela","tag-caballero","tag-garcia-lozano-m-cristina","tag-joaquin-poch-broto","tag-jose-frassena","tag-julian-sanz"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16797"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16797\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}