{"id":16813,"date":"2002-10-05T00:00:00","date_gmt":"2002-10-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-estructural-i-funcional-de-mutants-de-rodopsina-associats-a-retinosi-pigmentaria\/"},"modified":"2002-10-05T00:00:00","modified_gmt":"2002-10-05T00:00:00","slug":"caracterizacion-estructural-i-funcional-de-mutants-de-rodopsina-associats-a-retinosi-pigmentaria","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-estructural-i-funcional-de-mutants-de-rodopsina-associats-a-retinosi-pigmentaria\/","title":{"rendered":"Caracterizaci\u00f3n estructural i funcional de mutants de rodopsina associats a retinosi pigment\u00e1ria"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Andr\u00e9s Perni Ana M. <\/strong><\/h2>\n<p>La rodopsina es el fotopigmento de los bastones, las c\u00e9lulas fotorreceptoras de la retina de los vertebrados. Esta prote\u00edna es un receptor de siete h\u00e9lices transmembranales que pertenece a la familia de los receptores acoplados a prote\u00edna g (gpcr). Se han estudiado mutantes puntuales de la rodopsina relacionados con la retinosis pigmentaria (rp), una enfermedad degenerativa progresiva de la retina, utilizando t\u00e9cnicas de mutag\u00e9nesis dirigida y t\u00e9cnicas espectrosc\u00f3picas. Estos ha permitido aportar nuevos conocimientos sobre el estudio de la estructura-funci\u00f3n en la rodopsina. Hemos realizado el an\u00e1lisis de varias mutaciones asociadas a rp, localizadas en los diferentes dominios de la prote\u00edna: transmembranal, intradiscal y citoplasm\u00e1tico.  por otro lado se ha llevado a cabo un estudio detallado de diferentes mutaciones en la posici\u00f3n 125, asociada a rp, para aportar informaci\u00f3n precisa sobre la implicaci\u00f3n de este residuo en la estructura y el mecanismo de activaci\u00f3n del receptor.  mediante espectroscopia de absorci\u00f3n en el uv-vis se ha determinado la capacidad de regeneraci\u00f3n de las prote\u00ednas con el 11-cis-retinal. La capacidad de los mutantes de activar la prote\u00edna g ha sido determinada mediante espectroscopia de fluorescencia.  las mutaciones de rp g106w, g114d, p171q y h211r provocan un mal plegamiento de las prote\u00ednas ya que impiden la regeneraci\u00f3n con el crom\u00f3foro. Los mutantes de rodospsina m44t, r135l, v137m y l328p pueden unir 11-cis-retinal pero presentan una activaci\u00f3n de la prote\u00edna g alterada. El conjunto de resultados obtenidos de la caracterizaci\u00f3n de los mutantes en la posici\u00f3n 125, indican que este residuo es clave para mentener la estructura del bolsillo de uni\u00f3n del crom\u00f3foro.  esta posici\u00f3n afecta, adem\u00e1s de la estructura, la se\u00f1alizaci\u00f3n del receptor ya que modifica la conformaci\u00f3n \u00f3ptima del bolsillo de uni\u00f3n del crom\u00f3foro en el entorno del anillo de beta-ionona.  estos result<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizaci\u00f3n estructural i funcional de mutants de rodopsina associats a retinosi pigment\u00e1ria<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizaci\u00f3n estructural i funcional de mutants de rodopsina associats a retinosi pigment\u00e1ria <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Andr\u00e9s Perni Ana M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Aut\u00f3noma de barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 10\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Joan Manyosa Ribatallada<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: esteve Padr\u00f3s morell <\/li>\n<li> Valle mendoza Luis del (vocal)<\/li>\n<li> Carballo villari\u00f1o Jos\u00e9 Miguel (vocal)<\/li>\n<li>francesc Sepulcre s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andr\u00e9s Perni Ana M. La rodopsina es el fotopigmento de los bastones, las c\u00e9lulas fotorreceptoras de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[8036,52922,160,115,35,17],"tags":[52923,52925,2843,52926,21274,52924],"class_list":["post-16813","post","type-post","status-publish","format-standard","hentry","category-biofisica","category-biooptica","category-bioquimica","category-bioquimica-molecular","category-ciencias-de-la-vida","category-quimica","tag-andres-perni-ana-m","tag-carballo-villarino-jose-miguel","tag-esteve-padros-morell","tag-francesc-sepulcre-sanchez","tag-joan-manyosa-ribatallada","tag-valle-mendoza-luis-del"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16813"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16813\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16813"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}