{"id":16831,"date":"2002-11-05T00:00:00","date_gmt":"2002-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-antileishmanico-y-estudio-del-modo-de-accion-de-tres-derivados-alquil-lisofosfola%c2%adpidos\/"},"modified":"2002-11-05T00:00:00","modified_gmt":"2002-11-05T00:00:00","slug":"efecto-antileishmanico-y-estudio-del-modo-de-accion-de-tres-derivados-alquil-lisofosfola%c2%adpidos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-antileishmanico-y-estudio-del-modo-de-accion-de-tres-derivados-alquil-lisofosfola%c2%adpidos\/","title":{"rendered":"Efecto antileishmanico y estudio del modo de acci\u00f3n de tres derivados alquil-lisofosfol\u00edpidos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Samira Azzouz <\/strong><\/h2>\n<p>La leishmaniosis visceral esta causada por leishmania donovani, y causa altos n\u00fameros de muertes en gran parte del planeta. Los tratamientos usados contra la enfermedad son en la mayor\u00eda t\u00f3xicos y el par\u00e1sito les ha desarrollado resistencia.  en esta tesis se ha estudiado el modo de acci\u00f3n  de tres alquil-lisofosfol\u00edpidos (alps), la edelfosina, hexacedilfosfocolina y la ilmofosina, sobre el agente eitol\u00f3gico del kala-azar indio: leishmania donovani. As\u00ed, se han comprobado tanto los efectos de los tres compuestos sobre la multiplicaci\u00f3n de los promastigotes y amastigotes de l.Donovani, como la citotoxicidad de dichos f\u00e1rmacos sobre las c\u00e9lulas hospedadoras del par\u00e1sito.  tambi\u00e9n se ha puesto de manifiesto el efecto de los alquil-lisofosfol\u00edpidos (alps) sobre la bios\u00edntesis de adn, arn y prote\u00ednas y sobre la s\u00edntesis de prote\u00ednas de estr\u00e9s por el par\u00e1sito tratado. En la tesis, adem\u00e1s, se han comprobado los efectos de los f\u00e1rmacos sobre el metabolismo de la glucosa y sobre una enzima del metabolismo de los fosfol\u00edpidos.  la actividad de los alquil-lisofosfol\u00edpidos sobre leishmania donovani se ha evaluado en otros aspectos moleculares del par\u00e1sito; entre otros se han estudiado las variaciones del ph intracelular en los par\u00e1sitos como en los macr\u00f3fagos parasitados y el efecto de los compuestos sobre los intercambios reguladores de ph, como tambi\u00e9n se han evaluado los cambios sufridos en las fases del ciclo celular de los promastigotes y la inducci\u00f3n de apoptosis y de necrosis en el par\u00e1sito.  se ha obtenido una cepa del par\u00e1sito resistente a la hexadecilfosfocolina y la resistencia adquirida no se debe a una amplificaci\u00f3n g\u00e9nica.  los tres alquil-lisofosfol\u00edpidos ensayados muestran actividad frente a las formas promastigotas y amastigotas de l.Donovani, con mayor efecto frente a las formas intracelulares, actuando indirectamente sobre los macr\u00f3fagos parasitados. Los productos finales del metabolismo que s<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto antileishmanico y estudio del modo de acci\u00f3n de tres derivados alquil-lisofosfol\u00edpidos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto antileishmanico y estudio del modo de acci\u00f3n de tres derivados alquil-lisofosfol\u00edpidos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Samira Azzouz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Osuna Carrillo De Albornoz<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Mart\u00ednez fern\u00e1ndez <\/li>\n<li>Jorge  Antonio Guisantes del barco (vocal)<\/li>\n<li>francoise Petavy anne (vocal)<\/li>\n<li>Santiago Hern\u00e1ndez rodr\u00edguez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Samira Azzouz La leishmaniosis visceral esta causada por leishmania donovani, y causa altos n\u00fameros de muertes en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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