{"id":16833,"date":"2002-11-05T00:00:00","date_gmt":"2002-11-05T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-del-oxido-na%c2%adtrico-en-la-fibrosis-hepatica-tarda%c2%ada-inducida-por-ligadura-del-conducto-biliar-comun-efecto-del-tratamiento-con-s-adenosilmetionina\/"},"modified":"2002-11-05T00:00:00","modified_gmt":"2002-11-05T00:00:00","slug":"papel-del-oxido-na%c2%adtrico-en-la-fibrosis-hepatica-tarda%c2%ada-inducida-por-ligadura-del-conducto-biliar-comun-efecto-del-tratamiento-con-s-adenosilmetionina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-del-oxido-na%c2%adtrico-en-la-fibrosis-hepatica-tarda%c2%ada-inducida-por-ligadura-del-conducto-biliar-comun-efecto-del-tratamiento-con-s-adenosilmetionina\/","title":{"rendered":"Papel del \u00f3xido n\u00edtrico en la fibrosis hep\u00e1tica tard\u00edainducida por ligadura del conducto biliar com\u00fan. efecto del tratamiento con s-adenosilmetionina"},"content":{"rendered":"<h2>Tesis doctoral de <strong>  V\u00e1zquez Gil M. Jos\u00e9 <\/strong><\/h2>\n<p>La fibrosis hep\u00e1tica, se caracteriza por la alteraci\u00f3n en la s\u00edntesis y degradaci\u00f3n de los componentes de la matriz extracelular. Un modelo experimental de fibrosis hep\u00e1tica es el de ligadura del conducto biliar com\u00fan (lcb) que induce un da\u00f1o hep\u00e1tico colest\u00e1tico, pudiendo observarse el proceso fibr\u00f3tico a las tres semanas de la ligadura.  en la lcb, la expresi\u00f3n de la isoforma inducible de la \u00f3xido n\u00edtrico sintasa (nos) y la producci\u00f3n de \u00f3xido n\u00edtrico (no) est\u00e1n alteradas, mientras que los sistemas antioxidantes est\u00e1n deteriorados, disminuyendo tambi\u00e9n los niveles de s-adenosilmetionina (adomet). Adem\u00e1s, el no inhibe directamente la actividad de la metionina adenosil transferasa (mat), enzima responsable de la s\u00edntesis de adomet.  hemos estudiado en la lcb de 31 d\u00edas la administraci\u00f3n cr\u00f3nica, de aminoguanidina (ag) o ng-l-arginina-metil-\u00e9ster (l-name), adem\u00e1s del efecto del tratamiento con s-adenosilmetionina (s.Amet(r)).  nuestros resultados confirman la existencia de fibrosis de origin biliar, que se acompa\u00f1a de cambios hemodin\u00e1micos, de la funci\u00f3n hep\u00e1tica y del estado oxidativo.  a partir de ellos, podemos concluir que:  1,- en animales sin ligadura se expresan, tanto la nosi como la nose, la inducible en c\u00e9lulas parenquimatosas y la endotelial en territorios vasculares. En animales lcb, se manitene la localizaci\u00f3n y aumenta la expresi\u00f3n de ambas. La producci\u00f3n de no tambi\u00e9n aumenta.  2,- el tratamiento de las ratas, ligadas o no, con adomet reduce la s\u00edntesis de no de forma comparable al l-name o aminoguanidina. El adomet interfiere en alg\u00fan paso de la s\u00edntesis del no. Las tres sustancias parecen actuar en una v\u00eda sint\u00e9tica com\u00fan.  3,- en las ratas ligadas tratadas con adomet, s\u00f3lo o combinado con l-name o aminoguanidina, aumenta la bilirrubinuria. El adomet induce una activaci\u00f3n de las enzimas conjugantes renales y\/o hep\u00e1ticas.  4,- la administraci\u00f3n cr\u00f3nica de adomet, l-name<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel del \u00f3xido n\u00edtrico en la fibrosis hep\u00e1tica tard\u00edainducida por ligadura del conducto biliar com\u00fan. efecto del tratamiento con s-adenosilmetionina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel del \u00f3xido n\u00edtrico en la fibrosis hep\u00e1tica tard\u00edainducida por ligadura del conducto biliar com\u00fan. efecto del tratamiento con s-adenosilmetionina <\/li>\n<li><strong>Autor:<\/strong>\u00a0  V\u00e1zquez Gil M. Jos\u00e9 <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Salamanca<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/05\/2002<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alejandro Esteller  Perez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  L\u00f3pez rodr\u00edguez Mar\u00eda a. <\/li>\n<li>salvador Zamora navarro (vocal)<\/li>\n<li>Jos\u00e9 Miguel Lopez novoa (vocal)<\/li>\n<li>Javier Gonz\u00e1lez gallego (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de V\u00e1zquez Gil M. Jos\u00e9 La fibrosis hep\u00e1tica, se caracteriza por la alteraci\u00f3n en la s\u00edntesis y degradaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,155,35,9,817,3153,156,384,9386],"tags":[9693,9692,5695,3904,4252,52984],"class_list":["post-16833","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-clinicas","category-ciencias-de-la-vida","category-ciencias-medicas","category-fisiologia-humana","category-histologia-humana","category-patologia","category-patologia-clinica","category-salamanca","tag-alejandro-esteller-perez","tag-javier-gonzalez-gallego","tag-jose-miguel-lopez-novoa","tag-lopez-rodriguez-maria-a","tag-salvador-zamora-navarro","tag-vazquez-gil-m-jose"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16833","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=16833"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/16833\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=16833"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=16833"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=16833"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}